Characterization of low bone mass in young patients with thalassemia by DXA, pQCT and markers of bone turnover
Characterization of low bone mass in young patients with thalassemia by DXA, pQCT and markers of bone turnover
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DOI：
10.1016/j.bone.2011.03.765
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发表时间：
2011-06-01
期刊：
影响因子：
4.1
通讯作者：
Zemel, Babette S.
中科院分区：
文献类型：
--
作者：
Fung, Ellen B.;Vichinsky, Elliott P.;Zemel, Babette S.
之前使用双 X 射线吸收测定法 (DXA) 的报告表明，高达 70% 的重型地中海贫血 (Thal) 成人骨量较低。然而，很少有研究控制身体尺寸和青春期延迟，这些已知影响该人群骨量的变量。在本研究中，通过 DXA 评估脊柱和全身的骨矿物质含量和面密度（BMC、aBMD），并通过外周定量计算机断层扫描（pQCT）评估 Thal 受试者（n = 25,11 名男性，10 至 30 岁）和局部对照（n = 34、15 名男性，7 至 30 岁）的体积 BMD 和远端胫骨的皮质几何形状。骨骼结果的 Z 评分是根据大量健康儿童和年轻人样本的参考数据计算得出的。收集空腹血液和尿液，通过自我评估确定青春期状态，并通过书面调查问卷评估饮食摄入和体力活动。患有 Thal 的受试者年龄相似，但身高、体重和瘦体重指数 Z 分数较低（均为 p18 岁，n = 11），胫骨小梁 vBMD 较低（p = 0.03）、皮质面积、皮质 BMC、皮质厚度、骨膜周长和截面模量 Z 分数（所有 p
Previous reports using dual x-ray absorptiometry (DXA) suggest that up to 70% of adults with thalassemia major (Thal) have low bone mass. However, few studies have controlled for body size and pubertal delay, variables known to affect bone mass in this population. In this study, bone mineral content and areal density (BMC, aBMD) of the spine and whole body were assessed by DXA, and volumetric BMD and cortical geometries of the distal tibia by peripheral quantitative computed tomography (pQCT) in subjects with Thal (n = 25,11 male, 10 to 30 years) and local controls (n = 34, 15 male, 7 to 30 years). Z-scores for bone outcomes were calculated from reference data from a large sample of healthy children and young adults. Fasting blood and urine were collected, pubertal status determined by self-assessment and dietary intake and physical activity assessed by written questionnaires. Subjects with Thal were similar in age, but had lower height, weight and lean mass index Z-scores (all p18 years, n = 11) had lower tibial trabecular vBMD (p = 0.03), cortical area, cortical BMC, cortical thickness, periosteal circumference and section modulus Z-scores (all p