St. John's wort and Kava in treating major depressive disorder with comorbid anxiety: a randomised double-blind placebo-controlled pilot trial
St. John's wort and Kava in treating major depressive disorder with comorbid anxiety: a randomised double-blind placebo-controlled pilot trial
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DOI：
10.1002/hup.994
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发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Bone, Kerry M.
中科院分区：
文献类型：
--
作者：
Sarris, Jerome;Kavanagh, David J.;Bone, Kerry M.
目的首次报道圣约翰草（St. John's wort，SJW）与卡瓦（Kava）联合治疗伴焦虑障碍的抑郁症（Major Depression Disorder，MDD）的随机对照试验。安慰剂导入2周后。该试验具有交叉设计，在两个对照阶段中测试SJW和Kava与安慰剂，每个阶段为4周。结果在意向治疗（p = 0.047）和完成者分析（p = 0.003）中，SJW和Kava在第一个对照阶段中在Beck抑郁量表（BDI-II）上的自我报告抑郁症方面的减少显著大于安慰剂。但是，在交叉阶段。在延迟用药组中没有出现这些效应的复制。也没有显着的影响油焦虑或quality of life.Conclusion有一些证据表明，在一个小样本共病焦虑使用SJW和卡瓦的抗抑郁作用。不存在抗焦虑作用的可能解释可能包括与SJW的潜在相互作用、抑郁症的存在或卡瓦剂量不足。版权所有（c）2008约翰威利父子有限公司。
Objective We report the first randomised controlled trial (RCT) using it combination of St. John's wort (SJW) and Kava for the treatment of major depressive disorder (MDD) with comorbid anxiety.Methods Twenty-eight adults With MDD and co-occurring anxiety were recruited for a double-blind RCT. After a placebo run-in of 2 weeks. the trial had a crossover design testing SJW and Kava against placebo over two controlled phases, each of 4 weeks. The primary analyses used intention-to-treat and completer analysesResults On both intention-to-treat (p = 0.047) and completer analyses (p = 0.003), SJW and Kava gave a significantly greater reduction in self-reported depression on the Beck Depression Inventory (BDI-II) over placebo in the first controlled phase. However, in the Crossover phase. a replication of those effects in the delayed medication group did not occur. Nor were there significant effects oil anxiety or quality of life.Conclusion There was some evidence of antidepressant effects using SJW and Kava in a small sample with comorbid anxiety. Possible explanations for the absence of anxiolysis may include a potential interaction with SJW, the presence of depression, or an inadequate dose of Kava. Copyright (c) 2008 John Wiley & Sons, Ltd.