Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke
Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke
复制标题
循环 FABP4（脂肪酸结合蛋白 4）是急性缺血性中风患者的一种新型预后生物标志物
DOI：
10.1161/strokeaha.117.017128
复制
发表时间：
2017-06-01
期刊：
影响因子：
8.3
通讯作者：
Liu, Qiang
中科院分区：
文献类型：
--
作者：
Tu, Wen-Jun;Zeng, Xian-Wei;Liu, Qiang
背景和目的脂肪酸结合蛋白4（FABP 4）是一种细胞内的脂质伴侣，参与协调脂质转运和动脉粥样硬化的发生。本研究旨在观察FABP 4对中国急性缺血性stroke. Methods患者3个月预后的影响，在一项前瞻性多中心观察性研究中，FABP 4的血清浓度在入院时测量737例连续急性缺血性卒中患者的血浆中。FABP 4，美国国立卫生研究院卒中量表评分，和传统的危险因素的血清浓度进行了评估，以确定其价值，预测功能的结果和死亡率在3 months.Results-During随访期间，一个不利的功能结果被发现在260例（35.3%），和94例（12.8%）死亡。在比较FABP 4的第三和第四四个四分位数与第一个四分位数的多变量模型中，FABP 4的浓度与不良功能结局和死亡率相关。与参考类别（Q1-Q3）相比，Q4中FABP 4浓度的相对风险为4.77（95%置信区间[CI]，2.02-8.15; P
Background and Purpose-FABP4 (fatty acid-binding protein 4) is an intracellular lipid chaperone involved in coordination of lipid transportation and atherogenesis. This study aimed at observing the effect of FABP4 on the 3-month outcomes in Chinese patients with acute ischemic stroke.Methods-In a prospective multicenter observational study, serum concentrations of FABP4 were on admission measured in plasma of 737 consecutive patients with acute ischemic stroke. Serum concentrations of FABP4, National Institutes of Health Stroke Scale score, and conventional risk factors were evaluated to determine their value to predict functional outcome and mortality within 3 months.Results-During follow-up, an unfavorable functional outcome was found in 260 patients (35.3%), and 94 patients (12.8%) died. In multivariate models comparing the third and fourth quartiles to the first quartile of FABP4, the concentrations of FABP4 were associated with poor functional outcome and mortality. Compared with the reference category (Q1-Q3), the concentrations of FABP4 in Q4 had a relative risk of 4.77 (95% confidence interval [CI], 2.02-8.15; P