Sleep Terrors in Children: A Prospective Study of Twins
Sleep Terrors in Children: A Prospective Study of Twins
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DOI：
10.1542/peds.2008-1303
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发表时间：
2008-12-01
期刊：
影响因子：
8
通讯作者：
Montplaisir, Jacques
中科院分区：
文献类型：
--
作者：
Nguyen, Bich Hong;Perusse, Daniel;Montplaisir, Jacques
OBJECTIVE.越来越多的证据表明，遗传因素与睡眠恐惧的发生有关。双胞胎研究提供了关于遗传和环境因素的宝贵信息，这些因素可能会影响疾病的表现;然而，大多数以前关于睡眠恐惧的双胞胎研究都是回顾性的，或者样本太小，无法得出结论性的结果。这项大型前瞻性研究的目的是阐明遗传和环境因素对儿童期睡眠恐怖的影响。总共有390对同卵双胞胎和异卵双胞胎在出生时被招募进行纵向研究。在18个月和30个月大时，对双胞胎的亲生母亲进行问卷调查，评估睡眠恐惧的患病率和频率。通过问卷调查和基因分型确定接合性。计算每种类型双胞胎的患病率和多胎相关。使用结构方程模型来确定归因于加性遗传、共享和非共享环境因素的方差比例。结果。18个月和30个月时的睡眠恐怖患病率分别为36.9%和19.7%; 49%的受影响儿童为男孩，51%为女孩。18个月时，同卵双生子和异卵双生子的多区相关系数分别为0.63和0.36。在30个月时，这些值分别为0.68（单合子）和0.24（双合子）。我们的模型拟合分析表明，在18个月（43.7%的加性遗传效应和56.3%的非共享环境）和30个月（41.5%的加性遗传效应和58.5%的非共享环境）时，睡眠恐怖可以用2组分模型解释。这些结果有力地支持了睡眠恐惧的遗传性。睡眠恐怖症状的持续存在似乎也与遗传效应有关。儿科2008; 122：e1164-e1167
OBJECTIVE. There is growing evidence that genetic factors are involved in the occurrence of sleep terrors. Twin studies provide invaluable information regarding genetic and environmental factors that can affect the manifestation of the disease; however, most previous twin studies on sleep terrors were performed retrospectively or with a sample that was too small to yield conclusive results. The aim of this large prospective study was to clarify the genetic and environmental contributions to sleep terrors in childhood.METHODS. In all, 390 pairs of monozygotic and dizygotic twins were recruited at birth for a longitudinal study. The prevalence and frequency of sleep terrors were assessed at 18 and 30 months of age with a questionnaire administered to the biological mother of the twins. Zygosity was determined by a questionnaire and genotyping. The prevalence and polychoric correlation for each type of twins were calculated. Structural-equation modeling was used to determine the proportion of variance attributable to additive genetic, shared, and nonshared environmental factors.RESULTS. The prevalence of sleep terrors was 36.9% at 18 months and 19.7% at 30 months; 49% of affected children were boys, and 51% were girls. At 18 months, the polychoric correlations were 0.63 for monozygotic and 0.36 for the dizygotic twins. These were 0.68 (monozygotic) and 0.24 (dizygotic) at 30 months. Our model-fitting analysis showed that sleep terrors were explained by a 2-component model at 18 months (43.7% additive genetic effects and 56.3% nonshared environment) and at 30 months (41.5% additive genetic effects and 58.5% nonshared environment).CONCLUSIONS. These results strongly support the heritability of sleep terrors. There also seems to be continuity in genetic effects with the persistence of sleep-terror symptoms. Pediatrics 2008; 122: e1164-e1167