Circulating Tumor Cells and Colorectal Cancer.
Circulating Tumor Cells and Colorectal Cancer.
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DOI：
10.1007/s11888-010-0069-7
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发表时间：
2010-10-01
影响因子：
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通讯作者：
El-Deiry, Wafik S
中科院分区：
文献类型：
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作者：
Allen, Joshua E;El-Deiry, Wafik S
循环肿瘤细胞（CTC）的重要性已经讨论了超过世纪。现代技术的出现使CTC的检测更加可靠，最近的研究提供了令人信服的证据，表明CTC可预测转移性结直肠癌（mCRC）的临床反应。在一些研究中，CTC分析与独立预后因素的结合已证明具有强大的协同作用。CTC预测转移和治疗特异性反应的能力具有很高的潜在临床实用性，早期研究显示结直肠癌（CRC）的前景。可靠的CTC检测也允许在手术期间检查肿瘤细胞播散，并且似乎严重依赖于所选择的方法。这篇综述讨论了CTC意义的证据，特别关注CRC的检测方法、新标志物和临床结局。临床前、临床和转化研究存在许多机会来探索CTC内的分子决定因素，以及CTC在指导靶向治疗中的价值。
The significance of circulating tumor cells (CTCs) has been discussed for more than a century. The advent of modern technology has allowed for more reliable detection of CTCs, and recent studies have provided compelling evidence that CTCs predict clinical response in metastatic colorectal cancer (mCRC). Combination of CTC analysis with independent prognostic factors has demonstrated powerful synergy in some studies. The ability of CTCs to predict metastasis and therapy-specific response has high potential clinical utility, with early studies showing promising results in colorectal cancer (CRC). Reliable CTC detection has also allowed for examination of tumor cell dissemination during surgery, and there appears to be a heavy dependence on the approach chosen. This review discusses the evidence for CTC significance, with particular focus on detection methods, novel markers, and clinical outcomes in CRC. Numerous opportunities exist for preclinical, clinical, and translational studies to explore molecular determinants within CTCs, as well as the value of CTCs in directing targeted therapeutics.