A Bolus Dose of Ketamine Reduces the Amplitude of the Transcranial Electrical Motor-evoked Potential: A Randomized, Double-blinded, Placebo-controlled Study
A Bolus Dose of Ketamine Reduces the Amplitude of the Transcranial Electrical Motor-evoked Potential: A Randomized, Double-blinded, Placebo-controlled Study
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DOI：
10.1097/ana.0000000000000653
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发表时间：
2021-07-01
影响因子：
3.7
通讯作者：
Baba, Hiroshi
中科院分区：
文献类型：
--
作者：
Furutani, Kenta;Deguchi, Hiroyuki;Baba, Hiroshi
背景：小剂量氯胺酮推注或输注不影响经颅运动诱发电位（MEP）振幅，但剂量>= 1 mg/kg可降低MEP振幅。我们进行了一项随机，双盲，安慰剂对照研究，以评估氯胺酮（1毫克/公斤）对经颅电MEP.Methods的影响：20名女性患者（年龄12至18岁）与青少年特发性脊柱侧凸计划进行后路脊柱融合术随机分配接受氯胺酮或生理盐水。全麻诱导和维持采用丙泊酚和瑞芬太尼持续输注。MEP由超最大经颅电刺激引起。MEP记录在基线时获得，然后在氯胺酮（1 mg/kg）或盐水（0.1 ml/kg）给药后2、4、6、8和10分钟获得。主要终点是记录的左侧胫骨前肌的最小相对MEP振幅（峰-峰振幅，基线值的%）。结果：氯胺酮组和生理盐水组左侧胫前肌MEP最小波幅的中位数（四分位距）分别为基线值的26%（9%~ 34%）和87%（55%~ 103%）（P
Background:A low-dose bolus or infusion of ketamine does not affect transcranial electrical motor-evoked potential (MEP) amplitude, but a dose >= 1 mg/kg may reduce MEP amplitude. We conducted a randomized, double-blinded, placebo-controlled study to evaluate the effect of ketamine (1 mg/kg) on transcranial electrical MEP.Methods:Twenty female patients (aged 12 to 18 y) with adolescent idiopathic scoliosis scheduled to undergo posterior spinal fusion were randomly allocated to receive ketamine or saline. General anesthesia was induced and maintained with continuous infusions of propofol and remifentanil. MEP was elicited by supramaximal transcranial electrical stimulation. MEP recordings were obtained at baseline and then at 2, 4, 6, 8, and 10 minutes after administration of ketamine (1 mg/kg) or saline (0.1 ml/kg). The primary endpoint was the minimum relative MEP amplitude (peak-to-peak amplitude, % of baseline value) recorded from the left tibialis anterior muscle. The baseline amplitude recorded before test drug administration was defined as 100%.Results:Medians (interquartile range) minimum MEP amplitudes in the left tibialis anterior muscle in the ketamine and saline groups were 26% (9% to 34%) and 87% (55% to 103%) of the baseline value, respectively (P