MTERFD1 functions as an oncogene
MTERFD1 functions as an oncogene
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MTERFD1 作为癌基因发挥作用
DOI：
10.18632/oncotarget.11140
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发表时间：
2014-11
期刊：
影响因子：
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通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Zhang C;Wu N;Gao F;Cai J;Han J;Yang Y;Zhou C;Sun W;Xian L;Cheng Y;Li B;Cai J;Liu C
//朝雄张1、2、*、宁武3、*、付高1、*、家齐韩1、杨艳勇、川峰周1、孙为民4、临风先1、应成1、白龙里1、蔡建明1、刘聪1、放射内科，第二军医大学海军医学系，上海，200433，PR中国2军事医学研究所，成都军区，成都，610021，中国3呼吸内科，第二军医大学长海医院免疫科，上海，200433，中国4200433，中华人民共和国中国*这些作者对这项工作的贡献平等通信：蔡建明，电子邮件：蔡建明882003@163.com丛刘，电子邮件：victorliu20102020@163.com关键词：MTERFD1，癌症，预后，增殖，存活收到：2015.10.02接受：2016年6月16日发表：2016年8月9日摘要MTERFD1，又名MTERF3(线粒体转录终止因子3)，调节线粒体基因组的转录。MTERFD1是一种线粒体蛋白，在体内抑制哺乳动物线粒体DNA的启动。在本研究中，我们发现MTERFD1基因扩增和高表达存在于多种不同类型的肿瘤中。值得注意的是，MTERFD1基因的高表达与临床总生存率的降低有关。MTERFD1基因的过表达促进了肿瘤细胞的体内外生长，并使处于S期的细胞比例增加。综上所述，我们的数据首次表明MTERFD1在许多类型的癌症中是癌基因。
// Chaoxiong Zhang 1, 2, * , Ning Wu 3, * , Fu Gao 1, * , Jiaqi Han 1 , Yanyong Yang 1 , Chuanfeng Zhou 1 , Weimin Sun 4 , Linfeng Xian 1 , Ying Cheng 1 , Bailong Li 1 , Jianming Cai 1 , Cong Liu 1 1 Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, PR China 2 Institute of Military Medicine, Chengdu Military Region, Chengdu, 610021, China 3 Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China 4 Department of Immunology, Second Military Medical University, Shanghai, 200433, People’s Republic of China * These authors contributed equally to this work Correspondence to: Jianming Cai, email: caijianming882003@163.com Cong Liu, email: victorliu20102020@163.com Keywords: MTERFD1, cancers, prognosis, proliferation, survival Received: October 02, 2015 Accepted: June 16, 2016 Published: August 09, 2016 ABSTRACT MTERFD1, also named MTERF3 (mitochondrial transcription termination factor 3), regulates transcription of the mitochondrial genome. MTERFD1 is a mitochondrial protein that represses mammalian mitochondrial DNA initiation in vivo . In this study, we found that MTERFD1 gene amplification and high expression existed in many different types of cancer. Significantly, increased expression of MTERFD1 gene was correlated with lower overall survival rate in clinical. Overexpression of MTERFD1 gene promoted to tumor cell growth in vivo and in vitro and increased the percentage of cells in S phase. In conclusion, our data firstly indicated the MTERFD1 was an oncogene in many types of cancer.