Cohort Profile: LifeLines, a three-generation cohort study and biobank
Cohort Profile: LifeLines, a three-generation cohort study and biobank
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DOI：
10.1093/ije/dyu229
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发表时间：
2015-08-01
影响因子：
7.7
通讯作者：
Stolk, Ronald P.
中科院分区：
文献类型：
--
作者：
Scholtens, Salome;Smidt, Nynke;Stolk, Ronald P.
LifeLines 队列研究是一项基于大规模人群的队列研究和生物库，旨在为研究慢性病发展和健康老龄化过程中环境、表型和基因组因素之间的复杂相互作用提供资源。 2006年至2013年间，荷兰北部的居民及其家人受邀参与，从而为三代人的设计做出了贡献。参与者参观了生命线研究中心之一进行身体检查，包括肺功能、心电图和认知测试，并完成了广泛的调查问卷。收集了 167 729 名参与者的基线数据，年龄从 6 个月到 93 岁不等。每 5 年安排一次随访，并在两次随访期间参与者接受随访调查问卷。正在与医疗登记和环境数据建立联系。 LifeLines 包含生物化学、病史、社会心理特征、生活方式等信息。可获得基因组数据，包括 15 638 名参与者的全基因组遗传数据。空腹血液和 24 小时尿液样本在采集当天进行处理，并储存在 -80 摄氏度的全自动储存设施中。 LifeLines 的目标是成为国内和国际科学界的资源。数据和生物材料的请求可以提交给 LifeLines 研究办公室 [LLscience@umcg.nl]。
The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Participants visited one of the LifeLines research sites for a physical examination, including lung function, ECG and cognition tests, and completed extensive questionnaires. Baseline data were collected for 167 729 participants, aged from 6 months to 93 years. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. LifeLines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15 638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 degrees C in a fully automated storage facility. The aim of LifeLines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the LifeLines Research Office [LLscience@umcg.nl].