Prevention Effects Moderate the Association of 5-HTTLPR and Youth Risk Behavior Initiation: Gene x Environment Hypotheses Tested via a Randomized Prevention Design
Prevention Effects Moderate the Association of 5-HTTLPR and Youth Risk Behavior Initiation: Gene x Environment Hypotheses Tested via a Randomized Prevention Design
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DOI：
10.1111/j.1467-8624.2009.01288.x
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发表时间：
2009-05-01
影响因子：
4.6
通讯作者：
Murry, Velma McBride
中科院分区：
文献类型：
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作者：
Brody, Gene H.;Beach, Steven R. H.;Murry, Velma McBride
采用随机预防设计来研究5-HTTLPR位点SCL6A4（5HTT）基因多态性与青少年危险行为发生增加之间的关联调节作用。假设参加强大的非裔美国人家庭（SAAF）计划可以减弱5-HTTLPR状态与风险行为发生之间的联系。青少年（N = 641, M = 11.2岁）被随机分配到SAAF组或对照组。29个月的风险行为起始与5-HTTLPR基因型呈正相关，与SAAF参与呈负相关。控制有遗传风险的青年，在两种情况下，有遗传风险的SAAF青年和没有遗传风险的青年发起危险行为的比率是前者的两倍。
A randomized prevention design was used to investigate a moderation effect in the association between a polymorphism in the SCL6A4(5HTT) gene at 5-HTTLPR and increases in youths' risk behavior initiation. Participation in the Strong African American Families (SAAF) program was hypothesized to attenuate the link between 5-HTTLPR status and risk behavior initiation. Youths (N = 641, M age = 11.2 years) were assigned randomly to a SAAF or control condition. Risk behavior initiation across 29 months was linked positively with the 5-HTTLPR genotype and negatively with SAAF participation. Control youths at genetic risk initiated risk behavior at twice the rate of SAAF youths at genetic risk and youths not at genetic risk in either condition.