Quantitative Methods in Proteomics
Quantitative Methods in Proteomics
复制标题
蛋白质组学定量方法
作者：
K. Marcus
质谱法经常用于定量蛋白质组学中来检测差异调节的蛋白质。在检测差异蛋白时一个非常重要但不幸的是经常被忽视的部分是统计分析。蛋白质组学实验的数据通常是高维的，因此需要深入的统计方法。在实验室进行蛋白质组实验之前，正确设计蛋白质组实验尤为重要。只有这样才能保证之后的统计分析能够检测出真正的差异蛋白。因此，本章涵盖了定量蛋白质组实验的统计规划和实际分析的各个方面。
Mass spectrometry is frequently used in quantitative proteomics to detect differentially regulated proteins. A very important but unfortunately oftentimes neglected part in detecting differential proteins is the statistical analysis. Data from proteomics experiments are usually high-dimensional and hence require profound statistical methods. It is especially important to already correctly design a proteomic experiment before it is conducted in the laboratory. Only this can ensure that the statistical analysis is capable of detecting truly differential proteins afterwards. This chapter thus covers aspects of both statistical planning and the actual analysis of quantitative proteomic experiments.
影响因子：
4.4
作者：
Molina, Henrik;Yang, Yi;Ruch, Travis;Kim, Jae-Woo;Mortensen, Peter;Otto, Tamara;Nalli, Anuradha;Tang, Qi-Qun;Lane, M. Daniel;Chaerkady, Raghothama;Pandey, Akhilesh
通讯作者：
Pandey, Akhilesh
影响因子：
4.4
作者：
Meierhofer, David;Wang, Xiaorong;Huang, Lan;Kaiser, Peter
通讯作者：
Kaiser, Peter
影响因子：
16
作者：
Bonaldi, Tiziana;Straub, Tobias;Mann, Matthias
通讯作者：
Mann, Matthias