Killing the killer: natural killer cells to treat Ewing's sarcoma.
Killing the killer: natural killer cells to treat Ewing's sarcoma.
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DOI：
10.1158/1078-0432.ccr-10-1368
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发表时间：
2010-08-01
期刊：
影响因子：
--
通讯作者：
Verneris MR
中科院分区：
文献类型：
--
作者：
Ahn YO;Weigel B;Verneris MR
Cho 和同事表明，尤文氏肉瘤细胞对扩增的同种异体自然杀伤 (NK) 细胞高度敏感，部分通过 NKG2D 和 DNAM-1 依赖机制实现。他们还使用原位小鼠模型证明，辐射显着增强了 NK 细胞对这些肿瘤的杀伤力。
Cho and coworkers show that Ewing’s sarcoma cells are highly sensitive to expanded allogeneic natural killer (NK) cells, partially through a NKG2D and DNAM-1 dependent mechanism. Using an orthotopic murine model, they also demonstrate that irradiation significantly enhances the NK cell killing of these tumors.