Prognostic classification of Hodgkin disease in pathologic stage III, based on anatomic considerations.
Prognostic classification of Hodgkin disease in pathologic stage III, based on anatomic considerations.
复制标题
根据解剖学考虑，病理学 III 期霍奇金病的预后分类。
作者：
R. Desser;H. Golomb;J. Ultmann;D. Ferguson;E. Moran;M. Griem;J. Vardiman;Bruce Miller;Nina Oetzel;D. Sweet;E. Lester;J. Kinzie;R. Blough
研究了52例病态型III期霍奇金病患者，以确定受累腹部淋巴结的位置是否影响生存。治疗包括全淋巴结放疗加或不加后续联合化疗。最初的放射场是“扩展的地幔”，包括膈上淋巴结、脾门区和主动脉旁淋巴结至L2-L4水平。随后，对下主动脉旁区和髂区进行治疗（“下倒Y”）。局限于脾脏和/或脾脏、腹腔或门静脉淋巴结（“解剖亚期”III1）的患者比累及主动脉旁淋巴结、髂淋巴结或肠系膜淋巴结（“解剖亚期”III2）的患者有更有利的5年生存率：分别为93%和57% （p < 0.05）。在全淋巴结照射的基础上增加联合化疗与III2期患者的生存改善有关，但与III1期患者的生存改善无关。
Fifty-two patients with pathologic stage III Hodgkin disease were studied in an effort to determine whether location of involved abdominal nodes influenced survival. Treatment consisted of total nodal radiotherapy with or without subsequent combination chemotherapy. Th initial radiation field was the "extended mantle," which included supradiaphragmatic nodes, the splenic hilar area, and paraaortic nodes to the level of L2-L4. Subsequently, lower paraaortic and iliac regions were treated ("lower inverted Y"). Patients with disease limited to the spleen and/or splenic, celiac, or portal nodes ("anatomic substage" III1) had a more favorable 5-yr survival than did patients with involvement of paraaortic, iliac, or mesenteric nodes ("anatomic substage" III2): 93% versus 57%, respectively (p less than 0.05). The addition of combination chemotherapy to total nodal irradiation was associated with improved survival of patients in stage III2, but not of those in stage III1.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana