Effects of dietary wheat germ deprivation on the immune system in Wistar rats: a pilot study
Effects of dietary wheat germ deprivation on the immune system in Wistar rats: a pilot study
复制标题
DOI：
10.1016/s1567-5769(02)00116-9
复制
发表时间：
2002-09-01
影响因子：
5.6
通讯作者：
Andrighetto, G
中科院分区：
文献类型：
--
作者：
Chignola, R;Rizzi, C;Andrighetto, G
可以通过胃肠道进入身体组织的生物活性分子可以与免疫调节回路和效应器功能相互作用。其中包括植物凝集素。例如小麦胚芽（WG）凝集素，其构成人类饮食的常见组分并且每天靶向免疫系统。膳食中的生物活性分子可能是一种免疫调节信号。为了研究长期缺乏这种信号对免疫系统的可能影响，两组大鼠被喂食含有或不含WG的饮食。WG剥夺饮食诱导的初级和次级淋巴器官的淋巴细胞的功能性无反应状态，在体外刺激与T细胞有丝分裂原植物血凝素（PHA）和B细胞有丝分裂原脂多糖（LPS）的评价。免疫细胞的无反应状态可以通过注射在油中乳化的抗原与灭活的分枝杆菌（完全弗氏佐剂，CFA）来逆转。因此，饮食信号可以与免疫系统相互作用，可能影响其在个体发育期间的形成。(C)2002 Elsevier Science B.V.保留所有权利。
Bioactive molecules that can gain access to body tissues through the gastrointestinal tract may interact with immune regulatory circuits and effector functions. Among these are plant lectins. such as wheat germ (WG) agglutinin, which constitute common components of the human diet and target the immune system on a daily basis. Dietary bioactive molecules might be considered as immunomodulatory signals. To investigate the possible effects on the immune system of the long-term absence of such signals, two groups of rats were fed on a diet containing or deprived of WG. The WG-deprived diet induced a state of functional unresponsiveness in lymphocytes from primary and secondary lymphoid organs, as evaluated by in vitro stimulation with T cell mitogen phytohemoagglutinin (PHA) and B cell mitogen lypopolysaccarides (LPS). The unresponsive state of the immune cells could be reversed by injection of antigen emulsified in oil with inactivated mycobacteria (complete Freund's adjuvant, CFA) Dietary signals can thus interact with the immune system possibly influencing its shaping during ontogenesis. (C) 2002 Elsevier Science B.V. All rights reserved.