Drug-induced versus drug-triggered pemphigus.
Drug-induced versus drug-triggered pemphigus.
复制标题
药物引起的天疱疮与药物引发的天疱疮。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Sarah Brenner
中科院分区：
文献类型：
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作者：
Ronni Wolf;A. Tamir;Sarah Brenner
本文对112例诱发性天疱疮进行了回顾性分析。根据致病药物的化学结构将其分为三组，分析比较其临床、预后和实验室特征。我们的文献筛选表明，在大多数患者中，疾病的生物学进展和临床病程取决于诱导/触发药物的类型。青霉胺诱导的天疱疮或SH药物（含有巯基的药物）诱导的天疱疮患者在停药后分别有39.4%和52.6%的患者自发康复。由其他药物诱发天疱疮的患者仅15%的病例显示自发恢复。这些结果表明，与其他药物诱导的天疱疮患者相比，在青霉胺（或SH药物）诱导的天疱疮患者中，该药物在疾病的发病机制中发挥着重要作用。似乎青霉胺（和SH药物）实际上在大多数情况下会诱发天疱疮，而其他药物只会在有既往易感性的患者中引发疾病。
112 cases of induced pemphigus were reviewed. The causative drugs were divided into three groups according to their chemical structure, and the clinical, prognostic and laboratory characteristics were analyzed and compared. Our literature screening indicates that the biological progress and clinical course of the disease depend upon the type of the inducing/triggering drug in the majority of patients. Patients with penicillamine-induced pemphigus or with pemphigus induced by SH drugs (drugs containing a sulfhydryl radical) showed spontaneous recovery in 39.4 and 52.6%, respectively, once the drug was discontinued. Patients whose pemphigus was induced by other drugs showed spontaneous recovery in only 15% of the cases. These results indicate that in patients with pemphigus induced by penicillamine (or SH drugs), the drug plays a major role in the pathogenesis of the disease, as compared to patients with pemphigus induced by other drugs. It seems that penicillamine (and SH drugs) actually induces pemphigus in most of the cases, whereas other drugs only trigger the disease in patients with a previous predisposition.