Metabolic syndrome impairs physical function, health-related quality of life, and peripheral circulation in patients with intermittent claudication
Metabolic syndrome impairs physical function, health-related quality of life, and peripheral circulation in patients with intermittent claudication
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DOI：
10.1016/j.jvs.2006.02.042
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发表时间：
2006-06-01
影响因子：
4.3
通讯作者：
Parker, Donald E.
中科院分区：
文献类型：
--
作者：
Gardner, Andrew W.;Montgomery, Polly S.;Parker, Donald E.
目的：本研究旨在(1)探讨代谢综合征对外周动脉疾病（PAD）患者间歇性跛行、身体功能、健康相关生活质量和外周循环的影响；(2)确定外周血管功能是否可预测代谢综合征患者间歇性跛行和身体功能。有间歇性跛行和代谢综合征的患者（n = 133）与无代谢综合征的患者（n = 201）进行比较。评估患者的代谢综合征特征、pad特异性指标（包括踝/肱指数和跛行距离）、身体功能指标、健康相关生活质量以及血管闭塞3分钟后的小腿血流和经皮氧张力反应。代谢综合征患者的初始跛行距离（平均+/- SD）比对照组（128 121米比180米：L 166米）短29% (P = 0.018)，代谢综合征患者的绝对跛行距离（319 195米比409 255米）短22% （P = 0.025）。此外，代谢综合征患者的峰值摄氧量较低（P = 0.037）， 6分钟步行距离较短（P = 0.027），健康相关生活质量的六个领域值较低（P = 0.027）
Purpose: This study was conducted to (1) examine the effect of metabolic syndrome on intermittent clandication, physical function, health-related quality of life, and peripheral circulation in patients with peripheral arterial disease (PAD), and (2) determine whether peripheral vascular function was predictive of intermittent claudication and physical function in patients with metabolic syndrome.Methods. Patients limited by intermittent claudication and who had metabolic syndrome (n = 133) were compared with those without metabolic syndrome (n = 201). Patients were assessed on metabolic syndrome characteristics, PAD-specific measures consisting of ankle/brachial index and claudication distances, physical function measures, health-related quality of life, and calf blood flow and transcutaneous oxygen tension responses after 3 minutes of vascular occlusion.Results. Initial claudication distance (mean +/- SD) was 29% shorter (P =.018) in patients with metabolic syndrome than in the controls (128 121 meters vs 180 :L 166 meters), and absolute claudication distance was 22% shorter (P =.025) in those with metabolic syndrome (319 195 meters vs 409 255 meters). Furthermore, patients with metabolic syndrome had lower peak oxygen uptake (P =.037), a shorter 6-minute walk distance (P =.027), lower values on six domains of health-related quality of life (P