Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. 3. Determination of D-glucaric acid in serum, with special reference to its level after administration of d-glucuronolactone and D-glucarolactones to man.
Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. 3. Determination of D-glucaric acid in serum, with special reference to its level after administration of d-glucuronolactone and D-glucarolactones to man.
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哺乳动物D-葡萄糖醛酸代谢中葡萄糖二酸途径的研究。
DOI：
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发表时间：
1969
影响因子：
1.7
通讯作者：
M. Ishidate
中科院分区：
文献类型：
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作者：
M. Matsui;T. Kaizu;M. Okada;M. Ishidate
本文用比色法测定了人口服D-葡萄糖醛酸内酯（Ⅰ）或D-葡萄糖醛酸内酯（Ⅱ、Ⅲ）后血清D-葡萄糖二酸（V）的浓度，结果表明，给药后1h血清D-葡萄糖醛酸（V）浓度最高，同时血清β-葡萄糖醛酸酶活性最低，β-葡萄糖醛酸酶抑制作用最大。因此证明了I在体内转化为β-葡萄糖醛酸酶抑制剂。
Serum D-glucaric acid (V) level was determined by the colorimetric method, especially after oral administration of D-glucuronolactone (I) or D-glucarolactones (II, III) to man. The highest level was observed at one hour after administration simultaneously with the lowest level of serum β-glucuronidase activity as well as the maximal β-glucuronidase inhibition of serum. In vivo conversion of I into β-glucuronidase inhibitor was thus demonstrated.