Recent progression in the utilization of autophagy-regulating nature compound as anti-liver fibrosis agents
Recent progression in the utilization of autophagy-regulating nature compound as anti-liver fibrosis agents
复制标题
自噬调节天然化合物作为抗肝纤维化药物的研究进展
DOI：
10.1080/10286020.2016.1276168
复制
发表时间：
2017-01-01
影响因子：
1.7
通讯作者：
Liu, Hong
中科院分区：
文献类型：
--
作者：
Ge, Mao-Xu;He, Hong-Wei;Liu, Hong
肝纤维化是由肝炎病毒感染、药物毒性、自身免疫失衡等多种病因引起的慢性肝损伤后的创伤愈合反应。自噬是一种降解受损细胞器或聚集蛋白的细胞过程，参与了包括肝纤维化在内的多种人类疾病。然而，自噬在肝纤维化发病机制中的确切作用尚未阐明。越来越多的证据表明，一些天然化合物通过调节自噬活性而显示出抗纤维化的潜力。为了更好地了解自噬、肝纤维化和调节自噬的天然化合物之间的关系，本文重点介绍了天然化合物通过调节自噬治疗肝纤维化的最新进展。
Hepatic fibrosis is a wound-healing response to chronic liver injury caused by various pathogenesis, such as hepatitis virus infection, drugs toxicity and autoimmune imbalances. Autophagy, a cellular process degrading damaged organelles or aggregative proteins, participates in multiple human diseases including hepatic fibrosis. However, the precise role of autophagy in the pathogenesis of hepatic fibrosis is yet to be elucidated. Accumulated evidences indicate that several nature compounds exhibit anti-fibrotic potential through modulating autophagy activity. For a better understanding of the relationships among autophagy, hepatic fibrosis, and autophagy-regulating nature compounds, this review highlights the recent advancement of nature compounds treating hepatic fibrosis through regulating autophagy.