CCL3 Signaling in the Tumor Microenvironment
CCL3 Signaling in the Tumor Microenvironment
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DOI：
10.1007/978-3-030-36667-4_2
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Terpos, Evangelos
中科院分区：
文献类型：
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作者：
Ntanasis-Stathopoulos, Ioannis;Fotiou, Despoina;Terpos, Evangelos
在肿瘤微环境中，趋化因子在免疫细胞运输调节和免疫景观形成中发挥关键作用。CCL 3或巨噬细胞炎性蛋白-1 α（MIP-1 α），一种重要的趋化因子，涉及免疫监视和耐受，已成为实体瘤和血液恶性肿瘤的预后生物标志物。CCL 3发挥抗肿瘤和促肿瘤行为，这是背景依赖性的，突出了潜在的相互关联的信号级联的复杂性。目前针对CCL 3的治疗方法是研究性的，需要进一步优化以提高疗效并最大限度地减少不良事件。
Within the tumor microenvironment, chemokines play a key role in immune cell trafficking regulation and immune landscape formulation. CCL3 or macrophage inflammatory protein-1 alpha (MIP-1 alpha), an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies. CCL3 exerts both antitumor and pro-tumor behavior which is context dependent highlighting the complexity of the underlying interrelated signaling cascades. Current CCL3-directed therapeutic approaches are investigational and further optimization is required to increase efficacy and minimize adverse events.