Tissue expression of three structurally different fatty acid binding proteins from rat heart muscle, liver, and intestine.
Tissue expression of three structurally different fatty acid binding proteins from rat heart muscle, liver, and intestine.
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DOI：
10.1016/0006-291x(86)90314-1
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发表时间：
1986-06
影响因子：
3.1
通讯作者：
N. Bass;J. Manning
中科院分区：
文献类型：
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作者：
N. Bass;J. Manning
已从大鼠肝脏、小肠上皮和心肌中纯化了三种结构不同的 14-15 kDa 脂肪酸结合蛋白，并使用大鼠组织中的特异性抗血清进行了定量。心肌脂肪酸结合蛋白占心肌胞质蛋白的5%，也在胃、肌肉、睾丸、卵巢、肾、脑和脂肪组织中表达，其模式不同于肝蛋白（在肝、小肠上皮和大肠上皮以及脂肪组织中表达）和肠蛋白（在小肠和大肠上皮和胃中表达）。三种不同脂肪酸结合蛋白的组织表达的独特模式表明它们可能在脂肪酸转运和代谢中发挥不同的特定功能。
Three structurally different 14–15 kDa fatty acid binding proteins have have been purified from rat liver, small intestinal epithelium, and heart muscle, and were quantitated using specific antisera in rat tissues. Heart muscle fatty acid binding protein comprised 5% of heart muscle cytosol protein and was also expressed in stomach, muscle, testis, ovary, kidney, brain, and adipose tissue, a pattern distinct from both liver protein (expressed in liver, small and large intestinal epithelium, and adipose tissue) and intestinal protein (expressed in small and large intestinal epithelium and stomach). Distinctive patterns of tissue expression of the three different fatty acid binding proteins suggest that they may perform different specific functions in fatty acid transport and metabolism.