Clusterin in the male reproductive system: localization and possible function
Clusterin in the male reproductive system: localization and possible function
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DOI：
10.1016/s0303-7207(99)00016-7
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发表时间：
1999-05-25
影响因子：
4.1
通讯作者：
Griswold, MD
中科院分区：
文献类型：
--
作者：
Bailey, R;Griswold, MD
阿替丁是最初从男性生殖系统中分离的糖蛋白。随后，发现丛生蛋白广泛分布于哺乳动物的多种组织中。丛生蛋白表达的一个特征是它是由于细胞损伤、死亡或病理而被诱导的。尽管许多实验室在不同的生物系统中工作，但clusterin的功能仍然未知。最近的研究揭示了基因启动子中的“热休克元件”，这可能解释了丛生蛋白基因的诱导性质。总体而言，证据表明clusterin的功能是保护损伤后存活的细胞。这种保护作用可能是由于蛋白质的去污剂样作用。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Clustetin is a glycoprotein that was initially isolated from the male reproductive system. Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. One characteristic of the expression of clusterin is that it is induced as a result of cellular injury, death, or pathology. Despite the efforts of many laboratories working in diverse biological systems, the function of clusterin remains unknown. Recent studies have revealed a 'heat-shock element' in the promoter of the gene that may account for the inducible nature of the clusterin gene. Overall, the evidence suggests that function of clusterin is to protect surviving cells after damage. This protection may result from a detergent-like action of the protein. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.