Lifetime sport and leisure activity participation is associated with greater bone size, quality and strength in older men
Lifetime sport and leisure activity participation is associated with greater bone size, quality and strength in older men
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DOI：
10.1007/s00198-006-0114-1
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发表时间：
2006-08-01
影响因子：
4
通讯作者：
Bass, S. L.
中科院分区：
文献类型：
--
作者：
Daly, R. M.;Bass, S. L.
长期参加有规律的负重运动是否对老年人的骨骼结构和力量有好处尚不确定。本研究的目的是调查老年男性（50岁至50岁）终生运动和休闲活动对骨骼材料和轴尾骨骼结构特性的影响。方法：我们使用双能x线吸收仪（DXA）评估髋部、脊柱和桡骨超远端（UD）面骨矿物质密度（aBMD） （n=161），定量超声（QUS）测量足跟骨质量（n=161），定量计算机断层扫描（QCT）评估脊柱（L-1-L-3）和股骨中部（n=111）的体积骨密度、骨几何形状和强度。通过问卷调查评估青少年（13-18岁）和成年（19-50岁）目前（50岁以上）和过去参与体育和休闲活动的时间。这些信息被用来计算参加体育和休闲活动的总时间（分钟），以及每个参与者的成骨指数（OI）得分，这提供了参与负重活动的衡量标准。结果：回归分析显示，较大的终生（13-50岁以上）和成年中期（19-50岁）的成骨不全，但与总时间（min）无关，与股骨中部总量、皮质面积、皮质骨矿物质含量（BMC）、极转动惯量（I (p)）和足跟VOS （p范围从< 0.05到< 0.01）相关。这些结果与年龄、身高（或股骨长度）和体重（或肌肉横截面积）无关。青少年成骨不全评分未被发现是骨结构或强度的显著预测因子。此外，在任何部位均未检测到与面积或体积BMD的显著关系。然后根据受试者在青春期（13-18岁）和成年期（19-50岁以上）的成骨不全评分，将受试者分为高(H)组或低/无影响(L)组。随后形成三组来反映青春期和成年期的体重影响类别：LL， HL和HH。与LL组相比，HH组股骨中总股数、皮质面积、皮质BMC、I (p)增加6.5 ~ 14.2%。在LL组和HL组之间没有发现差异。结论：总之，这些发现表明，根据成骨指数（而不是参加所有运动和休闲活动的总时间（分钟））分类的长期定期参加体育和休闲活动是老年男性骨骼大小、质量和强度的重要决定因素，而不是骨密度。此外，在成年早期到中期继续参加负重运动似乎对降低老年时骨质强度低的风险很重要。
Introduction: It remains uncertain whether long-term participation in regular weight-bearing exercise confers an advantage to bone structure and strength in old age. The aim of this study was to investigate the relationship between lifetime sport and leisure activity participation on bone material and structural properties at the axial and appendicular skeleton in older men (> 50 years). Methods: We used dual-energy X-ray absorptiometry (DXA) to assess hip, spine and ultradistal (UD) radius areal bone mineral density (aBMD) (n=161), quantitative ultrasound (QUS) to measure heel bone quality (n=161), and quantitative computed tomography (QCT) to assess volumetric BMD, bone geometry and strength at the spine (L-1-L-3) and mid-femur (n=111). Current (> 50+ years) and past hours of sport and leisure activity participation during adolescence (13-18 years) and adulthood (19-50 years) were assessed by questionnaire. This information was used to calculate the total time (min) spent participating in sport and leisure activities and an osteogenic index (OI) score for each participant, which provides a measure of participation in weight-bearing activities. Results: Regression analysis revealed that a greater lifetime (13-50+ years) and mid-adulthood (19-50 years) OI, but not total time (min), was associated with a greater mid-femur total and cortical area, cortical bone mineral content (BMC), and the polar moment of inertia (I (p)) and heel VOS (p ranging from < 0.05 to < 0.01). These results were independent of age, height (or femoral length) and weight (or muscle cross-sectional area). Adolescent OI scores were not found to be significant predictors of bone structure or strength. Furthermore, no significant relationships were detected with areal or volumetric BMD at any site. Subjects were then categorized into either a high (H) or low/non-impact (L) group during adolescence (13-18 years) and adulthood (19-50+ years) according to their OI scores during each of these periods. Three groups were subsequently formed to reflect weight-bearing impact categories during adolescence and then adulthood: LL, HL and HH. Compared to the LL group, mid-femur total and cortical area, cortical BMC and I (p) were 6.5-14.2% higher in the HH group. No differences were detected between the LL and HL groups. Conclusions: In conclusion, these findings indicate that long-term regular participation in sport and leisure activities categorized according to an osteogenic index [but not the total time (min) spent participating in all sport and leisure activities] was an important determinant of bone size, quality and strength, but not BMD, at loaded sites in older men. Furthermore, continued participation in weight-bearing exercise in early to mid-adulthood appears to be important for reducing the risk of low bone strength in old age.