Conduction aphasia, sensory-motor integration, and phonological short-term memory - An aggregate analysis of lesion and fMRI data
Conduction aphasia, sensory-motor integration, and phonological short-term memory - An aggregate analysis of lesion and fMRI data
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DOI：
10.1016/j.bandl.2010.12.001
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发表时间：
2011-12-01
影响因子：
2.5
通讯作者：
Hickok, Gregory
中科院分区：
文献类型：
--
作者：
Buchsbaum, Bradley R.;Baldo, Juliana;Hickok, Gregory
传导性失语症是一种语言障碍，其特征是频繁的言语错误，逐字重复受损，语音短期记忆缺陷，以及在存在其他流利和语法的言语输出时命名困难。虽然传统的传导性失语模型通常涉及白色物质通路，但应用于患者组的病变重建方法的最新进展涉及左颞顶区。使用功能性磁共振成像（fMRI）的平行工作已经确定了左侧颞平面最后部分的一个区域，即Spt区，这对语音工作记忆至关重要。在这里，我们表明，在14例传导性失语症患者的样本中，最大病变重叠区域完全限定了Spt区，如在105名受试者进行语音工作记忆任务的汇总功能磁共振成像分析中定义的。我们提供了一个审查的证据支持的想法，即Spt是一个接口网站的感觉和声带相关的运动表征的复杂的声音序列，如语音和音乐的整合，并显示如何传导性失语症的症状可以解释这个系统的损害。(C)2011 Elsevier Inc. All rights reserved.
Conduction aphasia is a language disorder characterized by frequent speech errors, impaired verbatim repetition, a deficit in phonological short-term memory, and naming difficulties in the presence of otherwise fluent and grammatical speech output. While traditional models of conduction aphasia have typically implicated white matter pathways, recent advances in lesions reconstruction methodology applied to groups of patients have implicated left temporoparietal zones. Parallel work using functional magnetic resonance imaging (fMRI) has pinpointed a region in the posterior most portion of the left planum temporale, area Spt, which is critical for phonological working memory. Here we show that the region of maximal lesion overlap in a sample of 14 patients with conduction aphasia perfectly circumscribes area Spt, as defined in an aggregate fMRI analysis of 105 subjects performing a phonological working memory task. We provide a review of the evidence supporting the idea that Spt is an interface site for the integration of sensory and vocal tract-related motor representations of complex sound sequences, such as speech and music and show how the symptoms of conduction aphasia can be explained by damage to this system. (C) 2011 Elsevier Inc. All rights reserved.