WWOX, the tumour suppressor gene affected in multiple cancers.
WWOX, the tumour suppressor gene affected in multiple cancers.
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发表时间：
2009-05
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影响因子：
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通讯作者：
U. Lewandowska;M. Żelazowski;Karolina Seta;Magdalena Byczewska;E. Płuciennik;A. Bednarek
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作者：
U. Lewandowska;M. Żelazowski;Karolina Seta;Magdalena Byczewska;E. Płuciennik;A. Bednarek
WWOX是一种肿瘤抑制基因，影响多种癌症，特别是乳腺癌、前列腺癌和卵巢癌。该基因位于染色体16q23.3-24.1区域，被鉴定为染色体常见脆性位点FRA16D。尽管最基本（经典）的抑癌基因失活方式涉及两个等位基因（例如，通过缺失、点突变和启动子甲基化），但事实证明WWOX具有肿瘤抑制特征，这在WWOX病例中是非常罕见的事件，仅发生在少数细胞系中。大量文献证实了在许多不同类型的肿瘤中，如乳腺癌、非小细胞肺癌、膀胱癌、胃癌或散发性脑膜瘤中，WWOX表达缺失与更强侵袭性/更差预后之间存在相关性的现象。异位增加的WWOX表达促进了通过基膜的迁移，但抑制了锚定独立生长并诱导基质中正常样的集落形成。
WWOX is a tumour suppressor gene affected in multiple cancers, especially in breast, prostate and ovary. This gene is located at the chromosomal area 16q23.3-24.1, which was identified as a common chromosomal fragile site FRA16D. WWOX turned out to possess tumour suppressor features despite the fact that the most basic (classical) way of tumour suppressor gene inactivation involves both alleles (e.g. through deletions, point mutations and promoter methylation), which is very rare event in a case of WWOX, occurring only in few cell lines. A large number of papers corroborate the phenomenon of correlation between the loss of WWOX expression and more aggressive/worse prognosis in many different types of tumours, for example breast cancer, nonsmall cell lung cancer, bladder cancer, gastric cancer or sporadic meningiomas. Ectopically increased WWOX expression promotes migration through basal membrane, however suppresses anchorage independent growth and induces normal-like colony formation in matrigel.