Recent amplification of rat ID sequences
Recent amplification of rat ID sequences
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DOI：
10.1006/jmbi.1996.0464
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发表时间：
1996-08-23
影响因子：
5.6
通讯作者：
Deininger, PL
中科院分区：
文献类型：
--
作者：
Kim, J;Deininger, PL
啮齿动物重复序列的标识符（ID）家族在最近的进化时间中在大鼠基因组中以极高的速率扩增，导致每个单倍体基因组有130，000个拷贝。统计分析支持119个单独的大鼠ID元素分组为四个主要和三个次要的亚家族的基础上，六个诊断核苷酸的位置。最古老的亚家族的一致序列是相同的大鼠BCl RNA基因的ID区域，这表明BCl基因已占主导地位的大鼠ID元件的早期扩增。其他六个亚家族共享至少一个与BC1基因相关的诊断突变，并且显示出少得多的核苷酸序列差异，表明最近大鼠ID元件的大扩增是由大鼠基因组中的另一个谱系的主基因驱动的。这与在大鼠中形成用于ID扩增的主元件的新谱系一致。大多数老鼠ID元件的形成似乎发生在过去的300万年中，这是基于随机选择的5个ID元件中有4个只存在于一种老鼠物种的基因组中，而不存在于其他密切相关的物种中的结果。(C)出版社：Academic Press Limited。
The rodent identifier (ID) family of repeats has amplified at an extremely high rate in the rat genome in recent evolutionary time, resulting in 130,000 copies per haploid genome. Statistical analyses support the grouping of 119 individual rat ID elements into four major and three minor subfamilies based on six diagnostic nucleotide positions. The consensus sequence of the oldest subfamily is identical to the ID region of the rat BCl RNA gene, suggesting that the BCl gene has dominated the early amplification of rat ID elements. The other six subfamilies share at least one diagnostic mutation in relation to the BCl gene and show much less nucleotide sequence divergence, indicating that the recent large amplification of rat ID elements has been driven by another lineage of master gene(s) in the rat genome. This is consistent with the formation of a new lineage of master elements for ID amplification in rat. The formation of most rat ID elements appears to have occurred during the past three million years based on the results that four out of five randomly chosen ID elements are present only in the genome of one rat species and not in other closely related species. (C) 1996 Academic Press Limited.