Commonality in the microarchitecture of trabecular bone: A preliminary study
Commonality in the microarchitecture of trabecular bone: A preliminary study
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骨小梁微结构的共性：初步研究
DOI：
10.1016/j.bone.2018.03.003
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发表时间：
2018
期刊：
影响因子：
4.1
通讯作者：
Wang Xiaodu
中科院分区：
文献类型：
--
作者：
Zhao Feng;Kirby Matthew;Roy Anuradha;Hu Yizhong;Guo X Edward;Wang Xiaodu
了解松质骨的微观结构与力学功能之间的关系对于预测和预防骨脆性骨折至关重要。然而，对小梁微结构的结构设计的详细了解仍然缺失。本研究假设，存在一个共同的潜在的概率分布的骨小梁的微观结构特征，而个体之间的微观结构差异主要是由一组标量参数描述。为了检验这一假设，从两个解剖位置（即，股骨颈和椎体）和不同年龄和性别的17名供体的不同组。通过使用个体小梁分割（ITS）技术对3D μCT图像进行体积分解，确定松质骨样本中个体板和棒的数量、大小、空间位置和方向。然后，进行m/nbootstrap Kolmogorov-Smirnov检验，以比较标本中小梁板和棒的大小、方向和空间排列的归一化分布。结果表明，除了棒的空间排列分布（<100%）外，无论骨标本之间的个体差异如何，每个显微结构特征的23个标准化分布中的100%在统计学上是相等的。另一方面，非参数Mann-WhitneyU检验表明，一组标量参数（即，骨小梁板和骨小梁杆的数量、平均大小和平均最近邻距离）在个体标本之间具有统计学差异（P< 0.05）。由于潜在的分布的共性，个体之间的标本的小梁显微结构的差异似乎主要反映在标量参数的变化。上述结果有力地支持了本研究的假设，并可能为理解松质骨微结构的自然设计提供更多的线索。
Understanding the relationship between the microstructure and mechanical function of trabecular bone is critical for prediction and prevention of bone fragility fractures. However, a detailed understanding of the structural design of trabecular microarchitecture is still missing. This study hypothesized that there exists a commonality in the underlying probabilistic distributions of microstructural features of trabecular bones, whereas the microstructural differences among individuals are primarily describe by a set of scalar parameters. To test the hypothesis, twenty-three trabecular bone specimens were obtained from two anatomic locations (i.e., femoral neck and vertebral body) and a diverse group of seventeen donors of different age and sex. The number, size, spatial location, and orientation of individual plates and rods in the trabecular bone specimens were determinedviavolumetric decomposition of 3D μCT images using the Individual Trabecula Segmentation (ITS) technique. Then,m/nbootstrap Kolmogorov-Smirnov tests were performed to compare the normalized distributions of size, orientation, and spatial arrangement of trabecular plates and rods in the specimens. The results showed that 100% of the twenty-three normalized distributions of each microstructural feature were statistically equivalent irrespective of individual differences among the bone specimens, except the distributions of rod spatial arrangement (<100%). On the other hand, nonparametric Mann-WhitneyUtests showed that a set of scalar parameters (i.e., the number, average size, and average nearest neighbor distance of trabecular plates and rods) were statistically different among the individual specimens (p< 0.05). Due to the commonality of the underlying distributions, the individual differences in the trabecular microstructure among the specimens seemed to be reflected primarily by changes in the scalar parameters. The above results strongly support the hypothesis of this study and may shed more light on understanding the natural design of trabecular bone microstructures.