Molecular genetics of Drosophila immunity.
Molecular genetics of Drosophila immunity.
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DOI：
10.1016/0959-437x(94)90133-n
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发表时间：
1994-10
影响因子：
4
通讯作者：
Y. Ip;M. Levine
中科院分区：
文献类型：
--
作者：
Y. Ip;M. Levine
昆虫通过诱导细胞和体液免疫应答来抵抗细菌感染。细胞反应涉及血细胞的动员，而体液反应利用脂肪体中合成并分泌到循环血淋巴中的抗菌肽。最近的研究表明，体液反应的诱导涉及含Rel的调节蛋白，Dif和dorsal，它们与哺乳动物NF-κB相关。这些调节蛋白作为序列特异性转录因子发挥功能，诱导免疫基因的表达，包括天蚕素和蝶呤。在哺乳动物中，NF-κB参与淋巴细胞分化和急性期反应。昆虫和哺乳动物免疫涉及相关转录因子的发现为果蝇的遗传学研究可能导致鉴定介导哺乳动物免疫的新组分提供了希望。
Insect resist bacterial infections through the induction of both cellular and humoral immune responses. The cellular response involves the mobilization of hemocytes, whereas the humoral response utilizes antibacterial peptides that are synthesized in the fat bodies and secreted into the circulating hemolymph. Recent studies suggest that the induction of the humoral response involves Rel-containing regulatory proteins, Dif and dorsal, which are related to mammalian NF-κB. These regulatory proteins function as sequence-specific transcription factors that induce the expression of immunity genes, includingcecropinanddiptericin. In mammals, NF-κB has been implicated in both lymphocyte differentiation and the acute-phase response. The finding that insect and mammalian immunity involve related transcription factors offers the promise that genetic studies inDrosophilamight lead to the identification of novel components mediating mammalian immunity.