Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus
Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus
复制标题
DOI：
10.1002/jcb.25280
复制
发表时间：
2016-01-01
影响因子：
4
通讯作者：
Stein, Gary S.
中科院分区：
文献类型：
--
作者：
Fritz, Andrew J.;Barutcu, A. Rasim;Stein, Gary S.
间期染色体在染色体区域（CTs）中的组织是一百多年前首次提出的。越来越复杂的显微镜和分子技术的引入，现在提供了比以往任何时候都更深入地研究CT的补充策略。在这里，我们提供了一个概述，这些策略，以及它们如何被用来阐明CT的相互作用和这些动态调节，核结构的积木在直接支持核功能的生理反应的方式的作用。(C)2015 Wiley Periodicals，Inc.
The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear-structure building blocks in directly supporting nuclear function in a physiologically responsive manner. (C) 2015 Wiley Periodicals, Inc.