Control of LH secretory-burst frequency and interpulse-interval regularity in women
Control of LH secretory-burst frequency and interpulse-interval regularity in women
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DOI：
10.1152/ajpendo.00133.2003
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发表时间：
2003-11-01
影响因子：
5.1
通讯作者：
Veldhuis, JD
中科院分区：
文献类型：
--
作者：
Keenan, DM;Evans, WS;Veldhuis, JD
下丘脑神经元产生促性腺激素释放激素（GnRH）的离散爆发，从而以概率平均频率为中心的随机时间间隔产生促黄体生成激素（LH）脉冲。我们测试的假设，即生理机制不仅管理的数量，但也在人类的GnRH/LH脉冲更新过程的随机分散;例如，在年轻女性在月经周期的早期（EF）和晚期（LF）卵泡和黄体中期（ML）阶段（n = 18）和绝经后的个人（PM，n = 16）。为此，我们通过阶数无关的双参数威布尔更新过程（Keenan DM和Veldhuis J. Am J Physiol Regul Integr Comp Physiol 281：R1917-R1924，2001）和序列特异性的无模型近似熵统计（ApEn）（Pincus SM. Proc Natl Acad Sci USA 88：2297-2301，1991）。统计学检验揭示了1）LH分泌爆发频率的概率平均值降低ML与EF、LF和PM的比较（Weibull分布的较低λ）（P < 0.001）; 2）定量上更规则的LH爆发间期集（Weibull密度的伽马值升高），而不是EF、LF和ML ML组LH分泌高峰潜伏期明显延长（P < 0.01）;（P < 0.01）;（4）不同激素环境中随机、连续LH爆发间期和质量值（标准化ApEn）的平均值。从这些数据，我们假设，性类固醇和年龄决定每日LH分泌爆发数，可量化的脉冲更新的变异性，和分泌波形的演变。
Hypothalamic neurons generate discrete bursts of gonadotropin-releasing hormone (GnRH) and thereby pulses of luteinizing hormone (LH) at randomly timed intervals centered on a probabilistic mean frequency. We tested the hypothesis that physiological mechanisms govern not only the number but also the stochastic dispersion of the GnRH/LH pulse-renewal process in humans; for example, in young women in the early (EF) and late (LF) follicular and midluteal (ML) phases of the menstrual cycle (n = 18) and in postmenopausal individuals (PM, n = 16). To this end, we quantify stochastic interpulse variability by way of the order-independent, two-parameter Weibull renewal process (Keenan DM and Veldhuis J. Am J Physiol Regul Integr Comp Physiol 281: R1917-R1924, 2001) and the sequence-specific, model-free approximate-entropy statistic (ApEn) (Pincus SM. Proc Natl Acad Sci USA 88: 2297-2301, 1991). Statistical testing unveiled 1) reduced probabilistic mean LH secretory-burst frequency (lower lambda of the Weibull distribution) in ML compared with each of EF, LF, and PM (P < 0.001); 2) quantifiably more regular LH interburst-interval sets (elevated gamma of the Weibull density) in PM than in each of EF, LF, and ML (P < 0.01); 3) uniquely prolonged latency to maximal LH secretion within individual secretory bursts in ML (P < 0.01); and 4) comparably mean random, sequential LH interburst-interval and mass values ( normalized ApEn) among the distinct hormonal milieus. From these data, we postulate that sex steroids and age determine daily LH secretory-burst number, quantifiable pulse-renewal variability, and secretory-waveform evolution.