Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women
Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women
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DOI：
10.1007/s00125-012-2701-3
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发表时间：
2012-12-01
期刊：
影响因子：
8.2
通讯作者：
Balkau, B.
中科院分区：
文献类型：
--
作者：
Bonnet, F.;Disse, E.;Balkau, B.
适度饮酒与降低患2型糖尿病的风险有关，对女性的影响更大。由于其潜在的机制仍不明确，我们调查了其与胰岛素抵抗、胰岛素分泌、胰岛素清除和胰高血糖素浓度的关系。来自RISC(胰岛素敏感性和心血管疾病之间的关系)研究的1,276名非糖尿病患者没有高酒精摄入；在控制了年龄、中心、腰围、吸烟和体力活动后，女性和男性的酒精摄入量与胰岛素敏感性呈正相关(β=0.005.15，p(趋势)=0.0 7)。在女性中，这种联系在调整脂联素后持续存在，但在控制高密度脂蛋白-胆固醇后减弱，这表明部分保护与较高的高密度脂蛋白-胆固醇浓度有关。在女性中，较高的酒精摄入量仅与较低的基础胰岛素分泌有关(β=-0.10，p(趋势)=0.004)，在调整了胰岛素敏感性后，这种相关性仍然存在。在男性中，饮酒量增加与胰岛素清除增强和空腹NEFA浓度增加相关，与胰岛素敏感性无关。仅在女性中，空腹高血糖素随饮酒量的增加而降低(禁酒者9.2g/周8.6+/-4.0g/周；28-g/周8.1+/-3.7g；>；g/周7.5+/-3.1pmol/L；p(趋势)=0.01)。在健康女性中，轻度至中度饮酒与胰岛素敏感性增强、基础胰岛素分泌率降低和空腹血浆高血糖素浓度降低相关，为降低糖尿病风险提供了一致的机制。
Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes with a stronger effect in women. As the underlying mechanisms remain poorly characterised, we investigated its relationship with insulin resistance, insulin secretion, clearance of insulin and glucagon concentration.One-thousand two-hundred and seventy-six non-diabetic individuals from the RISC (relationship between insulin sensitivity and cardiovascular disease) study without high alcohol consumption were studied; all had a euglycaemic-hyperinsulinaemic clamp and an OGTT with assessment of insulin sensitivity, secretion and clearance.Alcohol consumption was positively associated with insulin sensitivity in women (beta = 0.15, p (trend) = 0.005) and in men (beta = 0.07, p (trend) = 0.07) after controlling for age, centre, waist, smoking and physical activity. In women, this association persisted after adjustment for adiponectin but was attenuated after controlling for HDL-cholesterol, suggesting that part of the protection is related to a higher HDL-cholesterol concentration. Higher alcohol consumption was associated with lower basal insulin secretion in women only (beta = -0.10, p (trend) = 0.004) and this association persisted after adjustment for insulin sensitivity. In men, increasing alcohol consumption was associated with enhanced insulin clearance and increased fasting NEFA concentrations, independently of insulin sensitivity. Fasting glucagon decreased with increasing alcohol in women only (abstainers 9.2 +/- 4.4; < 28 g/week 8.6 +/- 4.0; 28-64 g/week 8.1 +/- 3.7; > 64 g/week 7.5 +/- 3.1 pmol/l; p (trend) = 0.01).Light-to-moderate alcohol consumption was associated in healthy women with enhanced insulin sensitivity, reduced basal insulin secretion rate and lower fasting plasma glucagon concentration, providing consistent mechanisms for the reduced risk of diabetes.