Low-level mercury, omega-3 index and neurobehavioral outcomes in an adult US coastal population.
Low-level mercury, omega-3 index and neurobehavioral outcomes in an adult US coastal population.
复制标题
美国沿海成人人群的低水平汞、omega-3 指数和神经行为结果。
DOI：
10.1007/s00394-015-0890-5
复制
发表时间：
2016
影响因子：
5
通讯作者：
Meliker,JaymieR
中科院分区：
文献类型：
--
作者：
Vacchi-Suzzi,Caterina;Karimi,Roxanne;Kruse,Danielle;Silbernagel,SusanM;Levine,KeithE;Rohlman,DianeS;Meliker,JaymieR
研究背景：食用鱼类所产生的omega-3脂肪酸和汞对儿童神经发育的影响已被证实。相比之下，与鱼有关的神经行为结果在成人中还没有得到很好的研究。目的本研究对美国长岛（NY， USA）的海鲜消费者进行研究，旨在确定汞、海鲜消费、omega-3脂肪酸和神经行为结果之间的关系。方法采用计算机测试系统进行神经行为功能评估。研究人员对199名热衷于吃海鲜的成年人进行了血液中总汞（Hg）和omega-3指数的测量，这些人还完成了神经行为评估和广泛的食物、鱼类频率和人口调查问卷。结果对于大多数考虑的结果，在调整关键混杂变量后，Hg和omega-3指数都与神经行为结果无关。然而，食用鱼类与自我报告疲劳的几率降低（OR 0.85; 95% CI 0.72, 1.01）和一系列神经系统症状（OR 0.79; 95% CI 0.66, 0.96）相关。结论：我们的研究结果几乎没有证据表明ω -3脂肪酸或汞与成年海鲜爱好者的认知功能有关。需要更大规模的研究来证实我们的发现，即吃鱼与减少自我报告的疲劳和神经损伤之间存在关联。
BackgroundNeurodevelopmental effects of omega-3 fatty acids and mercury from fish consumption have been characterized in children. In contrast, neurobehavioral outcomes associated with fish are not well studied in adults.ObjectiveThis study of avid seafood consumers on Long Island (NY, USA) sought to define associations between mercury, seafood consumption, omega-3 fatty acids and neurobehavioral outcomes.MethodsA computer-based test system was used to assess neurobehavioral function. Blood total Hg (Hg) and omega-3 index were measured in 199 adult avid seafood eaters, who also completed the neurobehavioral assessment and an extensive food and fish frequency and demographic questionnaire.ResultsFor most of the outcomes considered, neither Hg nor omega-3 index was associated with neurobehavioral outcomes after adjustment for key confounding variables. Fish consumption, however, was associated with decreased odds of both self-reported fatigue (OR 0.85; 95 % CI 0.72, 1.01) and a constellation of neurologic symptoms (OR 0.79; 95 % CI 0.66, 0.96).ConclusionsResults from our study provide little evidence that omega-3 fatty acids or Hg is associated with cognitive function in adult avid seafood consumers. Larger studies are needed to confirm our finding of associations between fish consumption and decreased self-reported fatigue and neurologic impairment.