Mutation and senescence: where genetics and demography meet
Mutation and senescence: where genetics and demography meet
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DOI：
10.1023/a:1017047212008
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发表时间：
1998-01-01
期刊：
影响因子：
1.5
通讯作者：
Tatar, M
中科院分区：
文献类型：
--
作者：
Promislow, DEL;Tatar, M
两种进化遗传模型突变积累和拮抗多效性已被提出来解释衰老的起源和维持。本文主要研究突变累积模型。我们根据大规模人口统计学实验的新信息重新研究了以前的突变积累证据。在讨论了突变积累模型中提出的预测证据之后，我们详细讨论了两个关键问题。首先，我们讨论的可能性，经典的果蝇股票维护制度可能会引起虚假的结果，在选择研究老化。第二，我们考虑衰老进化模型的假设基础的证据。这些模型假设突变对年龄特异性存活率具有相加作用，存在其影响仅限于晚期年龄组的突变，并且所有突变具有相同的影响。最近的经验证据表明，这三个假设中的每一个都不太可能是正确的。基于这些结果，我们并不认为突变积累不再是衰老进化的有效解释。相反，我们建议我们现在需要开始开发更符合生物学现实的衰老进化遗传模型。
Two evolutionary genetic models-mutation accumulation and antagonistic pleiotropy-have been proposed to explain the origin and maintenance of senescence. In this paper, we focus our attention on the mutation accumulation model. We re-examine previous evidence for mutation accumulation in light of new information from large-scale demographic experiments. After discussing evidence for the predictions that have been put forth from models of mutation accumulation, we discuss two critical issues at length. First, we discuss the possibility that classical fruit fly stock maintenance regimes may give rise to spurious results in selection studies of aging. Second, we consider evidence for the assumptions underlying evolutionary models of aging. These models assume that mutations act additively on age-specific survival rate, that there exist mutations whose effects are confined to late age-classes, and that all mutations have equal effects. Recent empirical evidence suggests that each of these three assumptions is unlikely to be true. On the basis of these results, we do not conclude that mutation accumulation is no longer a valid explanation for the evolution of aging. Rather, we suggest that we now need to begin developing more biologically realistic genetic models for the evolution of aging.