TREATMENT ADHERENCE AND RISK OF DEATH AFTER A MYOCARDIAL-INFARCTION
TREATMENT ADHERENCE AND RISK OF DEATH AFTER A MYOCARDIAL-INFARCTION
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DOI：
10.1016/0140-6736(90)92095-y
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发表时间：
1990-09-01
期刊：
影响因子：
168.9
通讯作者：
SINDELAR, J
中科院分区：
文献类型：
--
作者：
HORWITZ, RI;VISCOLI, CM;SINDELAR, J
在Beta Blocker心脏病发作试验中，对2175名参与者进行了心肌梗死后治疗依从性与死亡率的关系调查，试验数据包括治疗依从性、临床严重性以及可能影响心肌梗死后死亡率的心理和社会特征。总体而言，没有很好坚持治疗方案的患者(即服用.ltoreq。75%的处方药物)在一年内死亡的可能性是良好依从者的2.6倍(95%可信区间，1.2，5.6)。依从性差的患者无论服用心得安(OR=3.1)还是安慰剂(OR=2.5)，死亡风险都会增加。此外，通过衡量心肌梗死的严重程度、社会人口特征(如种族、婚姻状况、教育)、吸烟或心理特征(高生活压力或社会孤立)，不能解释贫穷坚持者死亡风险的增加。
The relation of treatment adherence to mortality after a myocardial infarction was investigated among 2175 participants in the Beta Blocker Heart Attack Trial, which had data for measures of treatment adherence, clinical severity, and the psychological and social features that may influence post-infarction mortality. Overall, patients who did not adhere well to treatment regimen (ie, who took .ltoreq. 75% of prescribed medication) were 2.6 times more likely than good adherers to die within a year of follow-up (95% confidence interval, 1.2, 5.6). Poor adherers had an increased risk of death whether they were on propranolol (OR = 3.1) or placebo (OR = 2.5). Furthermore, this increased risk of death for poor adherers was not accounted for by measures of the severity of myocardial infarction, socio-demographic features (eg, race, marital status, education), smoking, or psychological characteristics (high life-stress or social isolation).