Reduced left angular gyrus volume in first-episode schizophrenia.
Reduced left angular gyrus volume in first-episode schizophrenia.
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DOI：
10.1176/appi.ajp.162.8.1539
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发表时间：
2005-08
期刊：
影响因子：
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通讯作者：
J. Nierenberg;D. Salisbury;J. Levitt;Elizabeth A David;R. McCarley;M. Shenton
中科院分区：
文献类型：
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作者：
J. Nierenberg;D. Salisbury;J. Levitt;Elizabeth A David;R. McCarley;M. Shenton
目的研究发现慢性精神分裂症患者的正常左大于右角回体积不对称性发生逆转。作者研究了首发精神分裂症患者的角回体积和不对称性是否异常。方法对14例首次住院的精神病患者和14例正常对照者进行磁共振成像检查。进行手动编辑以描绘中央后、边缘上和角回灰质体积。结果组间比较显示，患者左侧角回灰质体积较正常人减少14.8%。测量的其他区域均未显示出显著的组体积或不对称性差异。结论：新发精神分裂症患者的左角回体积比正常人小，这与精神分裂症患者顶叶体积异常的其他研究结果一致。首次发病患者的角回病理学提示角回可能是精神分裂症表达的神经解剖学基础。
OBJECTIVE Research suggests that the normal left-greater-than-right angular gyrus volume asymmetry is reversed in chronic schizophrenia. The authors examined whether angular gyrus volume and asymmetry were abnormal in patients with first-episode schizophrenia. METHOD Magnetic resonance imaging scans were obtained from 14 inpatients at their first hospitalization for psychosis and 14 normal comparison subjects. Manual editing was undertaken to delineate postcentral, supramarginal, and angular gyri gray matter volumes. RESULTS Group comparisons revealed that the left angular gyrus gray matter volume in patients was 14.8% less than that of the normal subjects. None of the other regions measured showed significant group volume or asymmetry differences. CONCLUSIONS Patients with new-onset schizophrenia showed smaller left angular gyrus volumes than normal subjects, consistent with other studies showing parietal lobe volume abnormalities in schizophrenia. Angular gyrus pathology in first-episode patients suggests that the angular gyrus may be a neuroanatomical substrate for the expression of schizophrenia.