Modular fluorescence sensors for saccharides
Modular fluorescence sensors for saccharides
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DOI：
10.1039/b108998f
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
James, TD
中科院分区：
文献类型：
--
作者：
Arimori, S;Bell, ML;James, TD
模块化的光诱导电子转移（PET）传感器轴承两个苯基硼酸基团，芘基团和亚烷基连接，从三亚甲基到八亚甲基，已制备和评价。相对于单硼酸4与D-葡萄糖的结合，具有四亚甲基3（4）、五亚甲基3（5）和六亚甲基3（6）接头的二硼酸系统显示出最大的结合增强。具有β 3（6）接头的二硼酸系统特别具有D-葡萄糖选择性和敏感性。同时，相对于单硼酸4与D-半乳糖的结合，具有较长的庚亚甲基3（7）和辛亚甲基3（8）接头的二硼酸系统显示出最大的增强。所有糖滴定均在甲醇水溶液中进行。
Modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid groups, a pyrene group and alkylene linkers, from trimethylene to octamethylene, have been prepared and evaluated. The diboronic acid systems with tetramethylene 3(4) pentamethylene 3(5) and hexamethylene 3(6) linkers display the greatest enhancement in binding relative to monoboronic acid 4 with D-glucose. The diboronic acid system with the hexamethylene 3(6) linker is particularly D-glucose selective and sensitive. Whilst the diboronic acid systems with the longer heptamethylene 3(7) and octamethylene 3(8) linkers display the greatest enhancement in binding relative to monoboronic acid 4 with D-galactose. All saccharide titrations were performed in methanolic aqueous solution.