Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength
Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength
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DOI：
10.1021/ja045263y
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发表时间：
2005-01-19
影响因子：
15
通讯作者：
Raymond, KN
中科院分区：
文献类型：
--
作者：
Pierre, VC;Botta, M;Raymond, KN
本文报道了一种新型树突状Gd螯合物Gd- trenn - bishopo - am - asp - asp2 - 12oh的合成及其弛豫性。由于具有12个末端羟基，该大分子的水溶性得到了改善；由于具有最佳的水交换速率和较慢的分子翻滚，该大分子的弛豫性得到了改善。在高磁场（90 MHz）下观察到前所未有的高弛豫（r1p= 18 mM-1s-1），这是下一代MRI扫描仪造影剂开发的重要进展。
The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p= 18 mM-1s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.