Peptide-Based Agents for Cancer Treatment: Current Applications and Future Directions.
Peptide-Based Agents for Cancer Treatment: Current Applications and Future Directions.
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基于肽的癌症治疗药物：目前的应用和未来的方向。
DOI：
10.3390/ijms241612931
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发表时间：
2023-08-18
影响因子：
5.6
通讯作者：
Yamada, Kaori H.
中科院分区：
文献类型：
--
作者：
Nhan, Nguyen Thi Thanh;Yamada, Tohru;Yamada, Kaori H.
基于肽的策略由于其特异性和适用性而受到极大的关注。它们的特异性和肿瘤靶向能力被应用于癌症患者的诊断和治疗。在这篇综述中，我们将总结基于肽的癌症治疗策略的最新进展和未来前景。进行文献检索以识别基于肽的癌症治疗策略的相关文章。使用PubMed对2023年6月之前的英文文章进行了评估。关于临床试验的信息也可从ClinicalTrial.gov获得.鉴于基于肽的策略具有几个优点，例如靶向递送至患病区域、个性化设计、相对小的尺寸和简单的生产工艺，具有抗癌活性的生物活性肽（抗癌肽或ACP）已经在临床前环境和临床试验中进行了测试.肽的肿瘤靶向能力对于肽-药物偶联物（PDC）、诊断和图像引导手术是基本上有用的。肽疫苗的免疫调节作用已在临床试验中得到广泛测试。尽管有这些优势，FDA批准的用于实体癌的肽类药物仍然有限。本综述将详细概述当前的方法、设计策略、给药途径和新的技术进步。我们将强调基于肽的癌症治疗的成功和局限性。
Peptide-based strategies have received an enormous amount of attention because of their specificity and applicability. Their specificity and tumor-targeting ability are applied to diagnosis and treatment for cancer patients. In this review, we will summarize recent advancements and future perspectives on peptide-based strategies for cancer treatment. The literature search was conducted to identify relevant articles for peptide-based strategies for cancer treatment. It was performed using PubMed for articles in English until June 2023. Information on clinical trials was also obtained from ClinicalTrial.gov. Given that peptide-based strategies have several advantages such as targeted delivery to the diseased area, personalized designs, relatively small sizes, and simple production process, bioactive peptides having anti-cancer activities (anti-cancer peptides or ACPs) have been tested in pre-clinical settings and clinical trials. The capability of peptides for tumor targeting is essentially useful for peptide–drug conjugates (PDCs), diagnosis, and image-guided surgery. Immunomodulation with peptide vaccines has been extensively tested in clinical trials. Despite such advantages, FDA-approved peptide agents for solid cancer are still limited. This review will provide a detailed overview of current approaches, design strategies, routes of administration, and new technological advancements. We will highlight the success and limitations of peptide-based therapies for cancer treatment.
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影响因子：
5.4
作者：
Alabsi W;Eedara BB;Encinas-Basurto D;Polt R;Mansour HM
通讯作者：
Mansour HM
影响因子：
39.3
作者：
Bai JW;Qiu SQ;Zhang GJ
通讯作者：
Zhang GJ
DOI：
10.1038/nrc2442
发表时间：
2008-08
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.2
作者：
Andre, Severine;Larbanoix, Lionel;Burtea, Carmen
通讯作者：
Burtea, Carmen
影响因子：
14
作者：
Balzeau, Julien;Pinier, Maud;Eyer, Joel
通讯作者：
Eyer, Joel