Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.
Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.
复制标题
载脂蛋白 A-IV 在大脑中枢起作用，可减轻大鼠胃溃疡的严重程度。
DOI：
10.1016/0006-8993(94)01432-h
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Pappas,TN
中科院分区：
文献类型：
--
作者：
Okumura,T;Taylor,IL;Fukagawa,K;Tso,P;Pappas,TN
我们最近报道了载脂蛋白A-IV（apoA-IV），一种与脂蛋白相关的蛋白质，在脑中起抑制胃酸分泌的作用。在本研究中，我们使用Sprague-Dawley大鼠确定apo A-IV是否具有通过中枢神经系统的抗溃疡作用。脑池内注射apo A-IV（2.0-4.0 μg/只）可剂量依赖性地减轻静脉注射2-脱氧-D-葡萄糖或皮下注射吲哚美辛引起的胃粘膜损伤。腹腔注射较高剂量（15 μg）的apo A-IV不能抑制这些致溃疡剂引起的胃粘膜损伤的发展。这些结果首次表明，载脂蛋白A-IV通过中枢机制具有抗溃疡作用。
We have recently reportd that apolipoprotein A-IV (apo A-IV), a protein associated with lipoproteins, acts in the brain to inhibit gastric acid secretion. In the present study, we determined whether or not apo A-IV has an anti-ulcer action via the central nervous system using Sprague-Dawley rats. Intracisternal injection of apo A-IV dose-dependently (2.0–4.0 μg/rat) reduced the severity of gastric mucosal lesions induced by intravenous injection of 2-deoxy-d-glucose or subcutaneous administration of indomethacine. A higher dose (15 μg) of apo A-IV injected intraperitoneally failed to inhibit the development of gastric mucosal damage evoked by these ulcerogenic agents. These results suggest for the first time that apo A-IV has an anti-ulcer action through a central mechanism.