Achromobacter xylosoxidans in cystic fibrosis:: Prevalence and clinical relevance
Achromobacter xylosoxidans in cystic fibrosis:: Prevalence and clinical relevance
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DOI：
10.1016/j.jcf.2006.05.011
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发表时间：
2007-01-01
影响因子：
5.2
通讯作者：
Vaneechoutte, Mario
中科院分区：
文献类型：
--
作者：
De Baets, Frans;Schelstraete, Petra;Vaneechoutte, Mario
背景资料：木糖氧化无色杆菌越来越多地培养在囊性纤维化（CF）患者的痰中，然而，很少有发表的数据对这种感染或慢性colonisation.Methods的临床影响：依靠DNA指纹技术，我们研究了A。我们的CF人群中的木糖氧化物。在一项回顾性病例对照研究中，对至少3次痰培养为A。在至少9个月内，在第一次阳性培养的时刻和在定殖期间，将至少9个月内的木糖氧化物与年龄（1岁）、性别和铜绿假单胞菌定殖控制的CF患者进行比较，这些患者从未患有A.结果：痰培养木糖氧化聚糖阳性的患者中，至少有一个阳性的A。木糖氧化物培养物为17.9%。5.3%的患者符合我们定义的定植标准。定植患者的中位年龄为20岁（范围11-27岁），平均定植时间为1.5（+/- 0.9）年。在首次阳性培养时，我们发现肺部HRCT扫描的Bhalla评分明显较低（11 +/- 3 vs 16 3，p < 0.05）。
Background: Achromobacter xylosoxidans is increasingly cultured in sputum from cystic fibrosis (CF) patients; nevertheless, there are few published data on the clinical impact of this infection or chronic colonisation.Methods: Relying on DNA fingerprinting techniques we studied the prevalence of A. xylosoxidans in our CF population. In a retrospective case control study the clinical status of patients with at least 3 sputum cultures positive for A. xylosoxidans over at least 9 months, at the moment of the first positive culture and during the period of colonisation were compared to age (1 year), gender and to Pseudomonas aeruginosa colonisation controlled CF patients who had never A. xylosoxidans positive sputum cultures.Results: The prevalence of patients with at least one positive A. xylosoxidans culture was 17.9%. 5.3% of the patients fulfilled the criteria of our definition of colonisation.Colonised patients had a median age of 20 years (range 11-27 years) and a mean colonisation period of 1.5 (+/- 0.9) years.At the moment of the first positive culture we found significantly lower Bhalla scores on HRCT scans of the lungs (11 +/- 3 versus 16 3, p