Prevalence of human papillomavirus type-18 in head and neck cancer among the Chinese population A PRISMA-compliant meta-analysis
Prevalence of human papillomavirus type-18 in head and neck cancer among the Chinese population A PRISMA-compliant meta-analysis
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中国人群头颈癌中 18 型人乳头瘤病毒的患病率 符合 PRISMA 标准的荟萃分析
DOI：
10.1097/md.0000000000014551
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发表时间：
2019
期刊：
影响因子：
1.6
通讯作者：
Guo Lanwei
中科院分区：
文献类型：
--
作者：
Yang Funa;Yin Yulin;Li Peng;Zhang Xiaojun;Chen Defeng;Liu Yang;Wang Jian;Guo Lanwei
背景：中国是全球头颈部癌的高负担国家，致癌性人乳头瘤病毒（HPV）已被假设为头颈部癌的危险因素，但缺乏确定HPV在中国患病率的研究。我们的目的是进行一项荟萃分析，以估计高危型HPV-18在中国人群的头颈癌患病率。方法：这项荟萃分析报告后，PRISMA的指导方针。检索CNKI/WANFANG/MEDLINE/EMBASE/科克伦数据库中2006年1月1日至2018年5月31日期间发表的中国人群HPV与头颈癌相关报道。随机效应模型被用来计算汇总患病率和相应的95%的置信区间。结果：共有1881头颈部癌症病例从19个研究纳入本荟萃分析。总体而言，头颈癌病例中HPV-18的合并患病率为6.0%，（4.1%-7.9%）在中国，31.2%喉癌13.0%~ 49.4%，（3.9%-10.5%）口腔癌和0.6%（0.0%-1.3%），口咽癌18.7%（6.2%-31.2%）新鲜或冷冻活检，4.3% E6/E7区阳性率为29.5%（15.6%~ 43.3%），L1区阳性率为3.9%（0.5%~ 7.4%）。结论：中国人头颈部癌组织中HPV-18感染率较高。预防性接种HPV疫苗可能会降低中国HPV相关头颈癌的负担。
Background:China has a high burden of head and neck cancer globally and oncogenic human papillomavirus (HPV) has been hypothesized as a risk factor for head and neck cancer, but research was absent for establishing HPV prevalence in China. We aimed to conduct a meta-analysis to estimate the high-risk HPV-18 prevalence of head and neck cancer in the Chinese population.Methods:This meta-analysis was reported following the guideline of PRISMA. The reports on HPV and head and neck cancer in a Chinese population published between Jan 1, 2006 and May 31, 2018 were retrieved via CNKI/WANFANG/MEDLINE/EMBASE/COCHRANE databases. A random-effect model was used to calculate pooled prevalence and corresponding 95% confidence intervals.Results:A total of 1881 head and neck cancer cases from 19 studies were included in this meta-analysis. Overall, the pooled HPV-18 prevalence among head and neck cancer cases was 6.0%(4.1%–7.9%) in China, 31.2%(13.0%–49.4%) in laryngeal cancer, 7.2%(3.9%–10.5%) in oral cancer and 0.6%(0.0%–1.3%) in oropharyngeal cancer, 18.7%(6.2%–31.2%) in fresh or frozen biopsies and 4.3%(2.5%–6.1%) in paraffin-embedded fixed biopsies, 29.5%(15.6%–43.3%) by E6/E7 region and 3.9%(0.5%–7.4%) by L1 region of HPV gene. The highest HPV-18 prevalence was found in Central China.Conclusions:High prevalence of HPV-18 was found in the samples of Chinese head and neck cancers. Prophylactic HPV-vaccination may reduce the burden of HPV-related head and neck cancer in China.