Intralesional injection of pingyangmycin is a safe and effective treatment for microcystic lymphatic malformations in the tongue
Intralesional injection of pingyangmycin is a safe and effective treatment for microcystic lymphatic malformations in the tongue
复制标题
病灶内注射平阳霉素治疗舌微囊性淋巴管畸形安全有效
DOI：
10.1258/phleb.2011.011082
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发表时间：
2013-04-01
期刊：
影响因子：
1.7
通讯作者：
Fan, X. D.
中科院分区：
文献类型：
--
作者：
Mai, H. M.;Zheng, J. W.;Fan, X. D.
目的评价病灶内注射平阳霉素治疗舌微囊性淋巴管畸形（LMs）的疗效和安全性。方法对18例舌微囊性LM患者进行病灶内注射平阳霉素治疗。添加地塞米松后药物浓度为 1 mg/mL。间隔3-4周重复注射。通过临床检查和多普勒超声扫描评估结果。随访期为最后一次治疗后12个月至8年，平均随访时间为3年。所有患者整个疗程均注射1~8次（平均3.0次）。平阳霉素总给药剂量为8~64 mg（平均24 mg）。结果 15 名患者获得完全缓解，没有出现外观或功能问题。三名巨舌症患者的病变大小减少了 50-90%，需要进行二次手术。没有遇到严重的并发症。结论 病灶内注射平阳霉素治疗舌微囊性LM是一种有效、安全的治疗方案，可作为一线治疗方案。
Objective To evaluate the efficacy and safety of intralesional injection of pingyangmycin for the treatment of microcystic lymphatic malformations (LMs) in the tongue. Methods Eighteen patients with tongue microcystic LMs were treated with intralesional injection of pingyangmycin. The concentration of the drug was 1 mg/mL with an addition of dexamethasone. Repeated injections were performed at an interval of 3–4 weeks. The results were evaluated by clinical examinations and Doppler ultrasonography scan. The follow-up period was 12 months to eight years after the last treatment and the mean follow-up time was three years. All patients received 1–8 injections (mean, 3.0 injections) for the whole course of treatment. The total dose of pingyangmycin administered was 8–64 mg (mean, 24 mg). Results Fifteen patients had complete response with no cosmetic or functional problems. Three patients with macroglossia had a reduction of 50–90% in the lesion size and needed secondary surgery. No serious complications were encountered. Conclusion The results suggested that intralesional injection of pingyangmycin is an effective and safe treatment for microcystic LMs in the tongue, and can be used as the first-line treatment protocol.