Peptide segment coupling in aqueous medium: silver ion activation of the thiolcarboxyl group.
Peptide segment coupling in aqueous medium: silver ion activation of the thiolcarboxyl group.
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DOI：
10.1111/j.1399-3011.1981.tb01992.x
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
J. Blake
中科院分区：
文献类型：
--
作者：
J. Blake
利用巯基羧基功能在水介质中组装脱锁肽段进行了研究。采用固相法合成了c端巯基肽Ac-Tyr-Arg-Arg-Glu-Arg-Gly-SH （2a）。在50%的二甲基甲酰胺水溶液中，肽2a的银化合物与h - ph - ala - glu - gly - oh偶联，得到40%产率的ac - tyr - arg - arg - glu - arg - gly - ph - ala - glu - gly - oh。
The use of the thiolcarboxyl function for the assemblage of deblocked peptide segments in aqueous medium has been investigated. The C-terminal thiolcarboxyl peptide Ac-Tyr-Arg-Arg-Glu-Arg-Gly-SH (2a) has been synthesized by the solid-phase method. The silver compound of peptide 2a was coupled to H-Phe-Ala-Glu-Gly-OH in 50% aqueous dimethylformamide to give a 40% yield of Ac-Tyr-Arg-Arg-Glu-Arg-Gly-Phe-Ala-Glu-Gly-OH.