Effect of Left Ventricular Assistance on Sympathetic Tone
Effect of Left Ventricular Assistance on Sympathetic Tone
复制标题
左心室辅助对交感神经张力的影响
DOI：
10.1177/039139889001301009
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
H. Takeda
中科院分区：
文献类型：
--
作者：
T. Yambe;S. Nitta;Y. Katahira;T. Sonobe;M. Tanaka;M. Miura;Naoshi Satoh;H. Mohri;M. Yoshizawa;H. Takeda
为了解左心室辅助装置(LVAD)泵入对交感神经张力的影响，在急性动物实验中检测了肾交感神经活动(RSNA)。我们研制的TH-7B型气动心室型辅助装置应用于7只成年杂种犬。用连接到左肾交感神经的双极电极检测RSNA。利用R-C积分器电路对RSNA进行放大和积分。在计算机系统中计算单位时间内的综合神经放电面积，并以单位时间内的RSNA表示。在LVAD泵浦过程中，RSNA随着血压的升高而降低，随着肺动脉流量的增加而增加，随着左房压力的降低而降低。这些数据表明，LVAD对交感神经系统有影响，交感神经系统由主动脉和心肺压力感受器反射系统介导。
To determine the effect of left ventricular assist device (LVAD) pumping on sympathetic tone, renal sympathetic nerve activity (RSNA) was detected in acute animal experiments. Our TH-7B pneumatically driven, sac-type ventricular assist device was used in 7 adult mongrel dogs. RSNA was detected by the use of bipolar electrodes attached to the left renal sympathetic nerve. RSNA was amplified and integrated by use of an R-C integrator circuit. The area of the integrated nerve discharge per unit time was calculated in the computer system and expressed as RSNA per unit time. During LVAD pumping, RSNA decreased with increase in blood pressure, with an increase in pulmonary artery flow, and with a decrease in left atrial pressure. These data suggest that LVAD has an effect on the sympathetic nervous system which is mediated by the aortic and cardiopulmonary baroreflex system.