Neuroinflammation imaging markers for epileptogenesis
Neuroinflammation imaging markers for epileptogenesis
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DOI：
10.1111/epi.13778
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发表时间：
2017-07-01
期刊：
影响因子：
5.6
通讯作者：
Baram, Tallie Z.
中科院分区：
文献类型：
--
作者：
Koepp, Matthias J.;Arstad, Eric;Baram, Tallie Z.
癫痫可以是一种毁灭性的疾病。除了使人衰弱的癫痫发作外，癫痫还可能导致认知和情感问题，降低生活质量。因此，主要目的是首先预防疾病：识别，检测和逆转导致其发病的过程，并监测和治疗其进展。癫痫通常在数月至数年的潜伏期（癫痫发生）后发生，这是脑损伤（如头部创伤、中风或癫痫持续状态）的结果。虽然这个潜伏期清楚地代表了一个治疗窗口，但我们无法对长期癫痫风险的患者进行分层，这是预防性临床试验的先决条件。此外，由于潜伏期的长度，治疗反应的早期生物标志物将具有很高的价值。最后，癫痫发生的机制生物标志物可能会提供更深刻的了解疾病的发展过程。
Epilepsy can be a devastating disorder. In addition to debilitating seizures, epilepsy can cause cognitive and emotional problems with reduced quality of life. Therefore, the major aim is to prevent the disorder in the first place: identify, detect, and reverse the processes responsible for its onset, and monitor and treat its progression. Epilepsy often occurs following a latent period of months to years (epileptogenesis) as a consequence of a brain insult, such as head trauma, stroke, or status epilepticus. Although this latent period clearly represents a therapeutic window, we are not able to stratify patients at risk for long-term epilepsy, which is prerequisite for preventative clinical trials. Moreover, because of the length of the latent period, an early biomarker for treatment response would be of high value. Finally, mechanistic biomarkers of epileptogenesis may provide more profound insight in the process of disease development.