Engineering ferrite nanoparticles with enhanced magnetic response for advanced biomedical applications
Engineering ferrite nanoparticles with enhanced magnetic response for advanced biomedical applications
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DOI：
10.1016/j.mtadv.2020.100119
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
Y. Wang;Y. Miao;G. Li;M. Su;X. Chen;H. Zhang;Y. Zhang;W. Jiao;Y. He;J. Yi;X. Liu-X.-L
中科院分区：
文献类型：
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作者：
Y. Wang;Y. Miao;G. Li;M. Su;X. Chen;H. Zhang;Y. Zhang;W. Jiao;Y. He;J. Yi;X. Liu-X.-L
磁性铁氧体纳米颗粒（MFNPs）在生物医学应用中最吸引人的特点之一是它可以介导外加磁场产生局部磁场、磁热效应和磁力效应。这些产生的效果以后可用于各种疾病的诊断和治疗。MFNPs的应用性能主要取决于其纳米磁性。因此，通过调制磁性能，可以改善MFNPs的磁共振（MR）信号、磁热和磁力学效应。在这篇综述中，我们总结了MFNPs工程中用于提高MR成像灵敏度和磁热转换效率的策略。我们还将详细讨论由MFNPs的临界磁性能引起的磁响应机制。此外，我们将重点介绍工程MFNPs在生物医学应用中的最新进展，重点是生物医学应用中的MR信号放大，磁热和磁力学响应。
One of the most attractive features of magnetic ferrite nanoparticles (MFNPs) in biomedical application is that they can mediate external magnetic field to produce local magnetic field, magnetic thermal and magnetic force effects. These generated effects can later be utilized in the diagnosis and treatment of various diseases. The application performance is mainly determined by the nano-magnetism of MFNPs. Therefore, by modulating the magnetic properties, the improved magnetic resonance (MR) signals, magnetothermal, and magnetomechanical effects of the MFNPs can be achieved. In this review, we summarize the strategies used in the engineering of MFNPs to enhance MR imaging sensitivity and magnetic thermal conversion efficiencies. We will also discuss the detailed magnetoresponsive mechanism arising from the critical magnetic properties of MFNPs. Furthermore, we will highlight the recent progresses of the engineered MFNPs in biomedical applications, with emphasis in MR signal amplification, magnetothermal, and magnetomechanical response in biomedical applications.