Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis
Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis
复制标题
DOI：
10.1016/j.neulet.2004.10.054
复制
发表时间：
2005-02-21
影响因子：
2.5
通讯作者：
Meyding-Lamadè, U
中科院分区：
文献类型：
--
作者：
Sellner, J;Dvorak, F;Meyding-Lamadè, U
单纯疱疹病毒脑炎（HSVE）患者的死亡率和发病率仍然很高。趋化因子介导的白细胞募集和活化到病毒中枢神经系统感染的病灶区域是抗病毒反应和清除的关键步骤。然而，炎症反应和细胞抗病毒反应可能会增加对神经元的附带损伤，并导致慢性进行性脑损伤。我们发现干扰素γ诱导的趋化因子（CXCL9、CXCL10和CXCL11）和RANTES （CCL5）在实验性HSVE的急性和长期病程中有特异性mRNA表达。这种模式被抗病毒和抗炎治疗大大改变。我们的发现表明这些趋化因子在HSVE的免疫发病机制中起关键作用。2004爱思唯尔爱尔兰有限公司版权所有。
Mortality and morbidity rates remain high among patients with herpes simplex virus encephalitis (HSVE). Chemokine-mediated recruitment and activation of leukocytes to focal areas of viral CNS infection are crucial steps in antiviral response and clearance. However, the inflammatory reaction and cellular antiviral response may enhance collateral damage to neurons and account for chronic progressive brain damage. We identified a specific mRNA expression of the interferon-gamma-inducible chemokines (CXCL9, CXCL10 and CXCL11), and RANTES (CCL5) in the acute course and long-term of experimental HSVE. This pattern was substantially altered by anti-viral and anti-inflammatory treatment. Our findings indicate a pivotal role of these chemokines in the immunopathogenesis of HSVE. (C) 2004 Elsevier Ireland Ltd. All rights reserved.