Evidence that Hensen's node is a site of retinoic acid synthesis
Evidence that Hensen's node is a site of retinoic acid synthesis
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汉森结是视黄酸合成位点的证据
作者：
B. Hogan;C. Thaller;G. Eichele
HENSEN的节点，就像两栖动物的Spemann组织者，可以诱导第二个身体轴时，移植到宿主胚胎1。鸟的节点，以及几个中线结构起源于它（脊索，底板），也可以诱导数字模式复制时，嫁接到鸡翅芽2，3。我们在这里报告，相当于Hensen的节点从小鼠是一个有效的诱导剂的数字在小鸡翅芽。淋巴结前后的组织也会引起模式重复，但效率明显较低。小鼠淋巴结在鸟类翅芽中起作用的发现表明，相同的诱导剂在初级和次级胚胎领域中起作用，并且在脊椎动物进化过程中被保守。数字模式复制也引起了局部管理的全反式维甲酸4，5。这种相似性提高了亨森结是视黄酸来源的可能性。小鼠淋巴结能够从其生物合成前体全反式视黄醇合成视黄酸，其速率比前组织或后组织高得多。
HENSEN'S node of amniotes, like the Spemann organizer of amphibians, can induce a second body axis when grafted into a host embryo1. The avian node, as well as several midline structures originating from it (notochord, floor plate), can also induce digit pattern duplications when grafted into the chick wing bud2,3. We report here that the equivalent of Hensen's node from mouse is an effective inducer of digits in the chick wing bud. Tissues anterior and posterior to the node also evoke pattern duplications, but with a significantly lower efficiency. The finding that the murine node operates in an avian wing bud suggests that the same inducing agent(s) function in both primary and secondary embryonic fields and have been conserved during vertebrate evolution. Digit pattern duplications are also evoked by local administration of all-trans-retinoic acid4,5. This similarity raises the possibility that Hensen's node is a source of retinoic acid. The mouse node is capable of synthesizing retinoic acid from its biosynthetic precursor all-trans-retinol at a substantially higher rate than either anterior or posterior tissues.
类维生素A和脊椎动物肢体模式的形成。
DOI：
10.1016/0168-9525(89)90096-6
发表时间：
1989
期刊：
Trends in genetics : TIG
影响因子：
--
作者：
Eichele,G
通讯作者：
Eichele,G
发育中的鸡肢芽中类视黄醇代谢的特征。
DOI：
10.1242/dev.103.3.473
发表时间：
1988
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Thaller,C;Eichele,G
通讯作者：
Eichele,G