Lineage-based analysis of the development of the central complex of the Drosophila brain.
Lineage-based analysis of the development of the central complex of the Drosophila brain.
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基于谱系的果蝇大脑中央复合体发育分析。
DOI：
10.1002/cne.22542
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Hartenstein,Volker
中科院分区：
文献类型：
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作者：
Pereanu,Wayne;Younossi-Hartenstein,Amelia;Lovick,Jennifer;Spindler,Shana;Hartenstein,Volker
中央复合体的大多数神经元属于10个次级（幼虫产生的）谱系。在晚期幼虫中，这些谱系的未分化轴突束形成一个原基，其中中央复合体的所有隔室都可以被识别为离散实体。四个后部谱系（DPMm 1，DPMpm 1，DPMpm 2和CM 4）产生了连接原脑桥，扇形体，结节和椭圆体的小视野神经元。位于前脑的三个谱系DALv 2、BAmv 1和DALcl 2分别形成椭圆体和扇形体的大视野神经元。这些谱系提供来自视结节的输入通道，并将中央复合体与相邻的前脑室连接起来。后皮质中的三个谱系CM 3、CP 2和DPMp 12将后脑神经元与扇形体的特定层连接。尽管中央复合体的所有隔室在晚期幼虫脑中由上述谱系的轴突束预示，但神经元在蛹期的前2天分化，此时次级神经元的终末分支和突触形成。在这个阶段，最初直的水平层的中央复合体弯曲在正面，这产生了扇形和椭圆体的特征形状。我们的分析提供了形成中央复合体的谱系的全面图片，并将促进未来在单细胞水平上解决中央复合体的结构或功能的研究。J. Comp.神经元519：661-689，2011.© 2010 Wiley利斯公司
Most neurons of the central complex belong to 10 secondary (larvally produced) lineages. In the late larva, undifferentiated axon tracts of these lineages form a primordium in which all of the compartments of the central complex can be recognized as discrete entities. Four posterior lineages (DPMm1, DPMpm1, DPMpm2, and CM4) generate the classes of small‐field neurons that interconnect the protocerebral bridge, fan‐shaped body, noduli, and ellipsoid body. Three lineages located in the anterior brain, DALv2, BAmv1, and DALcl2, form the large‐field neurons of the ellipsoid body and fan‐shaped body, respectively. These lineages provide an input channel from the optic tubercle and connect the central complex with adjacent anterior brain compartments. Three lineages in the posterior cortex, CM3, CP2, and DPMpl2, connect the posterior brain neuropil with specific layers of the fan‐shaped body. Even though all of the compartments of the central complex are prefigured in the late larval brain by the axon tracts of the above‐mentioned lineages, the neuropil differentiates during the first 2 days of the pupal period when terminal branches and synapses of secondary neurons are formed. During this phase the initially straight horizontal layers of the central complex bend in the frontal plane, which produces the characteristic shape of the fan‐shaped and ellipsoid body. Our analysis provides a comprehensive picture of the lineages that form the central complex, and will facilitate future studies that address the structure or function of the central complex at the single cell level. J. Comp. Neurol. 519:661–689, 2011. © 2010 Wiley‐Liss, Inc.