Daily antibiotic cost of nosocomial infections in a Turkish university hospital
Daily antibiotic cost of nosocomial infections in a Turkish university hospital
复制标题
土耳其大学医院医院感染的每日抗生素费用
作者：
D. Inan;R. Saba;F. Gunseren;G. Ongut;O. Turhan;A. Yalçın;L. Mamıkoğlu
背景许多研究将医院感染与因住院天数、工作人员时间、额外检查和药物治疗而增加的医院费用联系在一起。这些感染的抗生素治疗费用占医院支出的很大一部分。方法对2000年1月1日至2003年6月30日间入住ICU且住院期间仅发生一次院内感染的成人患者进行研究。记录感染部位、病原菌、患者抗菌治疗情况及费用。结果在研究的8460例患者中，817例(16.6%)发生了1407次医院感染。233例(2.7%)仅有一次院内感染。平均每天的抗生素费用为89.64美元。肺炎、血液感染、手术部位感染、尿路感染和其他感染的每日抗生素费用分别为99.02美元、94.32美元、94.31美元、52.37美元和162.35美元。铜绿假单胞菌感染的治疗是最昂贵的感染治疗。哌拉西林-他唑巴坦和阿米卡星是ICU中处方最多的抗生素，美罗培南是ICU治疗医院感染最昂贵的药物。结论医院感染的日抗生素费用是额外费用的重要组成部分，应在医院合理使用抗生素的情况下降低。
BackgroundMany studies associated nosocomial infections with increased hospital costs due to extra days in hospital, staff time, extra investigations and drug treatment. The cost of antibiotic treatment for these infections represents a significant part of hospital expenditure. This prospective observational study was designed to determine the daily antibiotic cost of nosocomial infections per infected adult patient in Akdeniz University Hospital.MethodsAll adult patients admitted to the ICUs between January 1, 2000, and June 30, 2003 who had only one nosocomial infection during their stay were included in the study. Infection sites and pathogens, antimicrobial treatment of patient and it's cost were recorded. Daily antibiotic costs were calculated per infected patient.ResultsAmong the 8460 study patients, 817 (16.6%) developed 1407 episodes of nosocomial infection. Two hundred thirty three (2.7%) presented with only one nosocomial infection. Mean daily antibiotic cost was $89.64. Daily antibiotic cost was $99.02 for pneumonia, $94.32 for bloodstream infection, $94.31 for surgical site infection, $52.37 for urinary tract infection, and $162.35 for the other infections per patient. The treatment of Pseudomonas aeruginosa infections was the most expensive infection treated. Piperacillin-tazobactam and amikacin were the most prescribed antibiotics, and meropenem was the most expensive drug for treatment of the nosocomial infections in the ICU.ConclusionsDaily antibiotic cost of nosocomial infections is an important part of extra costs that should be reduced providing rational antibiotic usage in hospitals.