Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
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DOI：
10.1016/j.clnu.2017.06.027
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发表时间：
2018-10-01
影响因子：
6.3
通讯作者：
Alfredo Martinez, J.
中科院分区：
文献类型：
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作者：
Cantero, Irene;Abete, Itziar;Alfredo Martinez, J.
背景和目标：在PREDIMED研究中，评估经验证的饮食炎症指数（DII）与特定饮食成分之间的可能关联，以及超重和肥胖受试者肝脏状态的适当非侵入性标志物。（平均+/- SD年龄：67.0 +/- 5.0岁，55%为女性）。DII是一种经验证的工具，用于评估饮食对六种炎症生物标志物（IL-1b、IL-4、IL-6、IL-10、TNF-α和C反应蛋白）的影响。此外，一个验证的137个项目的食物频率问卷被用来获得有关食物摄入的信息。此外，人体测量和几个非侵入性指标的肝脏状态进行了评估和脂肪肝指数（FLI）score calculated.Results：一个更高的DII和较低的坚持地中海饮食（MeDiet）与更高程度的肝损伤（FLI > 60）肥胖相比，超重的参与者。此外，DII评分与相关的非侵入性肝脏标志物（ALT、AST、GGT和FLI）呈正相关，并直接影响FLI值。有趣的是，肝损伤（>第50百分位数FLI）和营养素和食物与促炎饮食模式之间存在正相关性。结论：这项研究加强了肥胖与肝损伤相关的概念，并揭示了促炎饮食模式的消费可能有助于肥胖和脂肪肝疾病的特征。这些数据表明，精心设计的精确饮食，包括假定的抗炎成分，可以特别预防和改善非酒精性脂肪肝的表现，除了肥胖。(C)2017 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study.Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean +/- SD age: 67.0 +/- 5.0 y, 55% females) from the PREDIMED (PREvencion con Dleta MEDiterranea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-alpha and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated.Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern.Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.