Inhibitors of insulin-like growth factor signaling: A therapeutic approach for breast cancer
Inhibitors of insulin-like growth factor signaling: A therapeutic approach for breast cancer
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DOI：
10.1007/s10911-006-9010-8
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发表时间：
2006-01-01
影响因子：
2.5
通讯作者：
Yee, Douglas
中科院分区：
文献类型：
--
作者：
Sachdev, Deepali;Yee, Douglas
肽生长因子IGF-I和IGF-II不仅在乳腺的发育中起作用，而且还与乳腺癌有关。已经开发了几种破坏IGF信号传导的试剂，并且正在进行临床试验，以验证IGF信号传导作为癌症治疗的靶点。本文综述了乳腺癌中抑制IGF信号的方法。
The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.